Wiame Nicolas, Robert de Saint-Vincent Matthieu, Audag Nicolas, Aubriot Anne-Sophie, Penelle Morgane, Reychler Gregory, Patarin Jeremy, Poncin William
Faculté des Sciences de la Motricité, Université Catholique de Louvain, Louvain-La-Neuve, Belgium.
Rheonova, Allée de Certèze 1, 38610 Gières, France.
Respir Physiol Neurobiol. 2023 Oct;316:104125. doi: 10.1016/j.resp.2023.104125. Epub 2023 Jul 27.
Intrapulmonary percussive ventilation (IPV) has been postulated to enhance mucociliary clearance by improving tracheobronchial sputum rheological properties. The IPV effects on linear (viscoelasticity) and non-linear (flowing) rheological properties of 40 sputum samples collected from 19 patients with muco-obstructive lung diseases were investigated ex-vivo. Each sputum sample was split into 4 aliquots. These aliquots were independently placed in a circuit connected on one side to an IPV device and on the other side to a lung model that simulated spontaneous adult breaths. IPV was superimposed on simulated breathing. Three aliquots were exposed to a different IPV setting, modifying either percussion frequency or amplitude (4 Hz-200 L/min, 10 Hz-200 L/min, 10 Hz-140 L/min). One aliquot was only exposed to breathing (IPV was switched off, control condition). Each aliquot underwent 5 min of the pre-fixed mechanical stimulation before being recollected to proceed to rheological analysis. Neither percussion frequencies nor amplitudes had a significant impact on any sputum rheological properties studied. These results need to be confirmed in vivo.
