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儿童青光眼青光眼手术失败后微导管辅助环形小梁切开术

Microcatheter-Assisted Circumferential Trabeculotomy After Failed Glaucoma Surgeries in Childhood Glaucoma.

作者信息

Fang Lei, Zhu Yingting, Lin Shufen, Su Yihua, Chen Liming, Liu Pingping, Zhong Yimin, Liu Xing

机构信息

From the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases (L.F., Y.Z., S.L., L.C., P.L., Y.Z., X.L.), Guangzhou, China.

The Ophthalmology Department, the First Affiliated Hospital of Sun Yat-sen University (Y.S.), Guangzhou, China.

出版信息

Am J Ophthalmol. 2023 Dec;256:46-54. doi: 10.1016/j.ajo.2023.07.019. Epub 2023 Jul 27.

Abstract

PURPOSE

To evaluate the outcomes of microcatheter-assisted trabeculotomy (MAT) in childhood glaucoma (primary congenital glaucoma [PCG], juvenile open-angle glaucoma [JOAG], and secondary childhood glaucoma [SCG]) after failed glaucoma surgery.

DESIGN

Retrospective interventional case series.

METHODS

Patients with childhood glaucoma who underwent MAT after failed glaucoma surgery with at least 12 months of follow-up were evaluated. Pre- and postoperative intraocular pressure (IOP) and the number of glaucoma medications were recorded and compared. Success was defined as an IOP ≤21 mm Hg with or without glaucoma medication. Analysis of variance was used to compare the glaucoma subgroups.

RESULTS

Forty-five eyes (42 patients) with a median follow-up period of 19 months were included. The median age at the time of MAT was 10 (range, 0.8-33) years. The mean number of previous surgeries was 1.3 ± 0.5. The IOP had significantly reduced from baseline in all PCG, JOAG, and SCG patients (27.9 ± 4.5 vs 16.3 ± 8.0 mm Hg, P = .001; and 30.8 ± 9.4 vs 13.5 ± 3.0 mm Hg, P < .001; and 31.5 ± 7.1 vs 16.5 ± 5.3 mm Hg, P = .001, respectively). Fewer glaucoma medications were needed after MAT in all 3 groups (each P < .001). At the last visit, the total success rates in PCG, JOAG, and SCG were 93.8%, 100%, and 88.9%, respectively. No severe complications were observed.

CONCLUSION

MAT can effectively manage PCG, JOAG, and SCG after failed surgeries, providing successful outcomes and no serious complications. Following failed glaucoma surgeries, MAT may offer these patients with childhood glaucoma an excellent opportunity to achieve IOP control.

摘要

目的

评估在青光眼手术失败后,微导管辅助小梁切开术(MAT)治疗儿童青光眼(原发性先天性青光眼[PCG]、青少年开角型青光眼[JOAG]和继发性儿童青光眼[SCG])的疗效。

设计

回顾性干预病例系列研究。

方法

对青光眼手术失败后接受MAT且随访至少12个月的儿童青光眼患者进行评估。记录并比较术前和术后的眼压(IOP)及青光眼药物使用数量。成功定义为眼压≤21 mmHg(无论是否使用青光眼药物)。采用方差分析比较青光眼亚组。

结果

纳入45只眼(42例患者),中位随访期为19个月。MAT时的中位年龄为10岁(范围0.8 - 33岁)。既往手术的平均次数为1.3±0.5次。所有PCG、JOAG和SCG患者的眼压均较基线水平显著降低(分别为27.9±4.5 vs 16.3±8.0 mmHg,P = 0.001;30.8±9.4 vs 13.5±3.0 mmHg,P < 0.001;31.5±7.1 vs 16.5±5.3 mmHg,P = 0.001)。所有3组患者在MAT后所需的青光眼药物均减少(每组P < 0.001)。在最后一次随访时,PCG、JOAG和SCG的总成功率分别为93.8%、100%和88.9%。未观察到严重并发症。

结论

MAT可有效治疗手术失败后的PCG、JOAG和SCG,疗效良好且无严重并发症。在青光眼手术失败后,MAT可为这些儿童青光眼患者提供控制眼压的良好机会。

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