Charles G, Schittecatte M, Maes J M, Rush A J, Wilmotte J
Acta Psychiatr Belg. 1986 May-Jun;86(3):249-56.
We assessed the length and the quality of the remission of 13 unipolar endogenous depressed DST nonsuppressors before treatment in a 2-year prospective study. During this period, we recorded stressful life events. Persistent dexamethasone non-suppression after treatment and complete clinical recovery correlated highly with early clinical relapse. All six nonnormalizers but only one normalizer were rehospitalized within the following two years for a major depressive relapse. Persistent DST nonsuppression was unrelated to any impact of drug discontinuation, to the occurrence of stressful life events or to the length of illness-free intervals in the patient's prior course of illness. Persistent DST non-suppression appears to have a significant prognostic value.
在一项为期两年的前瞻性研究中，我们评估了13例治疗前为单相内源性抑郁且地塞米松抑制试验（DST）不被抑制的患者缓解期的时长和质量。在此期间，我们记录了应激性生活事件。治疗后持续的地塞米松不被抑制与完全临床康复和早期临床复发高度相关。在接下来的两年内，所有6例未恢复正常者因重度抑郁复发再次住院，而恢复正常者中只有1例再次住院。持续的DST不被抑制与停药的任何影响、应激性生活事件的发生或患者既往病程中无病间期的时长均无关。持续的DST不被抑制似乎具有显著的预后价值。
