肥胖女性中通过生物电阻抗测定的肌肉量与循环抵抗素水平的关系。

Relationship of circulating resistin levels with muscle mass determined by bioelectrical impedance in females with obesity.

机构信息

Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valladolid, Valladolid, Spain; Centro de Investigación de Endocrinología y Nutrición (CIEN), Universidad de Valladolid, Valladolid, Spain.

出版信息

Endocrinol Diabetes Nutr (Engl Ed). 2023 Aug-Sep;70(7):468-475. doi: 10.1016/j.endien.2023.03.023. Epub 2023 Jul 27.

DOI:10.1016/j.endien.2023.03.023

PMID:37516610

Abstract

INTRODUCTION

Serum resistin levels have been associated with obesity, visceral fat, and insulin resistance. Its relationship with muscle mass has been less evaluated.

OBJECTIVES

to evaluate the relationship between muscle mass determined by electrical bioimpedance and circulating resistin levels in obese women over 60 years of age.

METHODS

We conducted a cross-sectional study in 313 obese women. Anthropometric data (weight, height, body mass index (BMI) and waist circumference), BIA parameters (total fat mass (TFM), fat-free mass (FFM), fat-free mass index (FFMI)), skeletal muscle mass (SMM) and skeletal muscle mass index (SMI)), blood pressure and laboratory tests were recorded.

RESULTS

Patients were divided into two different groups according to the mean value of SMI (11.93 kg/m): low SMI versus high SMI. In the low SMI group, the resistin levels were higher than the resistin levels in the high SMI group (delta value: 2.8 + 0.3 ng/dl:p = 0.01). Serum resistin levels are inversely correlated with FFM, FFMI, SMM, and SMI. This adipokine shows a positive correlation with insulin, HOMA-IR and PCR levels. In the model with SMI as the dependent variable, resistin levels explained 12% of the variability in muscle mass (Beta -0.38, 95% CI -0.91 to -0.11).

CONCLUSIONS

Serum resistin levels are associated with low skeletal muscle mass in obese women over 60 years of age.

摘要

简介

血清抵抗素水平与肥胖、内脏脂肪和胰岛素抵抗有关。其与肌肉量的关系评估较少。

目的

评估通过电阻抗生物阻抗法测定的肌肉量与 60 岁以上肥胖女性循环抵抗素水平之间的关系。

方法

我们对 313 名肥胖女性进行了横断面研究。记录了人体测量学数据（体重、身高、体重指数（BMI）和腰围）、BIA 参数（总脂肪量（TFM）、无脂肪量（FFM）、无脂肪量指数（FFMI））、骨骼肌量（SMM）和骨骼肌量指数（SMI））、血压和实验室检查。

结果

根据 SMI 的平均值（11.93kg/m）将患者分为两组：低 SMI 组与高 SMI 组。在低 SMI 组，抵抗素水平高于高 SMI 组（差值：2.8+0.3ng/dl：p=0.01）。血清抵抗素水平与 FFM、FFMI、SMM 和 SMI 呈负相关。这种脂肪因子与胰岛素、HOMA-IR 和 PCR 水平呈正相关。在以 SMI 为因变量的模型中，抵抗素水平解释了肌肉量变异性的 12%（Beta-0.38，95%CI-0.91 至-0.11）。