Müller H F, Achim A, Laur A, Buchbinder A
Acta Psychiatr Scand. 1986 Jun;73(6):665-75. doi: 10.1111/j.1600-0447.1986.tb02741.x.
The topography and possible physiological significance of EEG average amplitude and amplitude variability in time were examined in 10 chronic psychotic patients and several groups of healthy volunteers. In confirmation of previous reports, the patients showed more slow (5.2-7.6 Hz) activity, particularly in frontal areas, and less alpha rhythm variability in posterior areas, compared to matched controls, chiefly during the resting state, while eye opening, and particularly structural sensory input, made the groups more similar. The same two EEG variables showed significant correlations with ratings of psychopathology, in the expected direction. The EEG amplitude variability is increased by unstructured perception, probably as an expression of readiness or search for structures in the input, and shows persistent topographic patterns over time in individuals. It appears to reflect a functional dimension which is different from the one represented by the average amplitude and is one of several spontaneous oscillatory functions which are diminished in chronic psychosis, perhaps as consequence of prefrontal malfunction. The results suggest a diminished guiding function by the anterior cortex, and a diminished readiness for perception of exogenous structured information, in chronic psychosis.
对10名慢性精神病患者和几组健康志愿者的脑电图平均振幅和时间上的振幅变异性的地形学特征及其可能的生理意义进行了研究。与匹配的对照组相比，正如之前报告所证实的那样，患者主要在静息状态下，表现出更多的慢波（5.2 - 7.6赫兹）活动，尤其是在额叶区域，而后部区域的α波变异性较小，睁眼时，特别是结构性感觉输入时，两组表现更为相似。这两个脑电图变量与精神病理学评分在预期方向上存在显著相关性。非结构化感知会增加脑电图振幅变异性，这可能是对输入中的结构进行准备或搜索的一种表现，并且在个体中随时间呈现出持续的地形学模式。它似乎反映了一个与平均振幅所代表的功能维度不同的功能维度，并且是慢性精神病中减弱的几种自发振荡功能之一，这可能是前额叶功能障碍的结果。结果表明，在慢性精神病中，前皮质的引导功能减弱，对外源性结构化信息的感知准备也减弱。
