Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
Faculdade de Medicina, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, MG, Brazil.
Behav Brain Res. 2023 Sep 13;453:114605. doi: 10.1016/j.bbr.2023.114605. Epub 2023 Jul 28.
Menopause is the period in which women cease to produce the hormone estrogen, which can trigger physiological, cognitive, and behavioral changes. In this context, alternatives are needed that can reduce the effects provided by menopause, specifically in terms of cognitive and behavioral aspects. High-intensity interval training (HIIT) is an exercise protocol that has shown the potential to improve cognition by promoting an increase in antioxidant defenses and BDNF levels. Therefore, the aim of this study was to evaluate the effects of HIIT on behavior and hippocampal neurochemistry in ovariectomized adult rats. Four groups of rats were divided into: females without ovariectomy surgery and sedentary (SHAM-SED); females with ovariectomy surgery and sedentary (OVX-SED); females without ovariectomy surgery and trained (SHAM-HIIT); females with ovariectomy surgery and trained (OVX-HIIT). After the surgical procedure and the HIIT protocol, the animals underwent anxiety (elevated plus maze and open field) and memory (novel object recognition) tests. Corticosterone was measured in blood and BDNF levels and redox status were evaluated in the hippocampus. The OVX-SED group showed low BDNF levels and antioxidant enzymes, which may be linked to the observed memory impairments. The HIIT protocol (SHAM-HIIT and OVX-HIIT groups) increased the BDNF levels and antioxidant enzymes in the hippocampus, improving the animals' memory. However, HIIT also led to increased plasma corticosterone and anxiety-like behaviors. The ovariectomy procedure induced memory impairment probably due to reductions in hippocampal BDNF levels and redox imbalance. The HIIT protocol demonstrates promising results as an alternative to improve memory in ovariectomized rats.
更年期是女性停止产生雌激素的时期，雌激素会引发生理、认知和行为变化。在这种情况下，需要寻找可以减轻更年期影响的替代方法，特别是在认知和行为方面。高强度间歇训练（HIIT）是一种运动方案，已显示出通过促进抗氧化防御和 BDNF 水平的增加来改善认知的潜力。因此，本研究旨在评估 HIIT 对去卵巢成年大鼠行为和海马神经化学的影响。将四组大鼠分为：未接受卵巢切除术且不运动的雌性大鼠（SHAM-SED）；接受卵巢切除术且不运动的雌性大鼠（OVX-SED）；未接受卵巢切除术且接受训练的雌性大鼠（SHAM-HIIT）；接受卵巢切除术且接受训练的雌性大鼠（OVX-HIIT）。手术后和 HIIT 方案后，动物进行焦虑（高架十字迷宫和旷场）和记忆（新颖物体识别）测试。测量血液中的皮质酮和 BDNF 水平，并评估海马中的氧化还原状态。OVX-SED 组的 BDNF 水平和抗氧化酶较低，这可能与观察到的记忆障碍有关。HIIT 方案（SHAM-HIIT 和 OVX-HIIT 组）增加了海马中的 BDNF 水平和抗氧化酶，改善了动物的记忆。然而，HIIT 也导致血浆皮质酮和焦虑样行为增加。卵巢切除术导致记忆障碍可能是由于海马 BDNF 水平降低和氧化还原失衡所致。HIIT 方案作为改善去卵巢大鼠记忆的一种替代方法具有广阔的前景。
