Another Breach in the Wall: Impaired Epithelial DUOX2 Activity Fuels Metabolic Syndrome.
作者信息
Parlato Marianna, Cerf-Bensussan Nadine
机构信息
Université Paris-Cité, Institut Imagine, Laboratory of Intestinal Immunity, INSERM U1163, Paris, France.
Université Paris-Cité, Institut Imagine, Laboratory of Intestinal Immunity, INSERM U1163, Paris, France.
出版信息
Cell Mol Gastroenterol Hepatol. 2023;16(4):648-649. doi: 10.1016/j.jcmgh.2023.07.005. Epub 2023 Jul 28.
Abstract
摘要
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本文引用的文献
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Intestinal Epithelial Inactivity of Dual Oxidase 2 Results in Microbiome-Mediated Metabolic Syndrome.双氧化酶 2 导致肠道上皮细胞无活力进而引发微生物组介导的代谢综合征。
Cell Mol Gastroenterol Hepatol. 2023;16(4):557-572. doi: 10.1016/j.jcmgh.2023.06.009. Epub 2023 Jun 25.
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The global burden of metabolic disease: Data from 2000 to 2019.全球代谢性疾病负担：2000 年至 2019 年的数据。
Cell Metab. 2023 Mar 7;35(3):414-428.e3. doi: 10.1016/j.cmet.2023.02.003.
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Sexual dimorphism in glucose metabolism is shaped by androgen-driven gut microbiome.雄激素驱动的肠道微生物组塑造了葡萄糖代谢的性别二态性。
Nat Commun. 2021 Dec 6;12(1):7080. doi: 10.1038/s41467-021-27187-7.
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DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk.DUOX2 变体与微生物群-免疫稳态的临床前紊乱和炎症性肠病风险增加有关。
J Clin Invest. 2021 May 3;131(9). doi: 10.1172/JCI141676.
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Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study.在超重和肥胖的人类志愿者中补充 Akkermansia muciniphila：概念验证性探索性研究。
Nat Med. 2019 Jul;25(7):1096-1103. doi: 10.1038/s41591-019-0495-2. Epub 2019 Jul 1.
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The Global Epidemic of the Metabolic Syndrome.代谢综合征的全球流行。
Curr Hypertens Rep. 2018 Feb 26;20(2):12. doi: 10.1007/s11906-018-0812-z.
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First Identification of Biallelic Inherited DUOX2 Inactivating Mutations as a Cause of Very Early Onset Inflammatory Bowel Disease.首次鉴定出双等位基因遗传性DUOX2失活突变是极早发型炎症性肠病的一个病因。
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A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice.阿克曼氏菌黏液亚种的纯化膜蛋白或巴氏杀菌细菌可改善肥胖和糖尿病小鼠的代谢。
Nat Med. 2017 Jan;23(1):107-113. doi: 10.1038/nm.4236. Epub 2016 Nov 28.
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Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus.2型糖尿病风险、病理生理学及并发症中的性别差异
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Defects in NADPH Oxidase Genes and in Very Early Onset Inflammatory Bowel Disease.NADPH氧化酶基因缺陷与极早发型炎症性肠病
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