Yamahara Naoki, Kimura Akio, Shimohata Takayoshi
Department of Neurology, Gifu University Graduate School of Medicine.
Rinsho Shinkeigaku. 2023 Aug 29;63(8):497-504. doi: 10.5692/clinicalneurol.cn-001871. Epub 2023 Jul 29.
Recent studies have demonstrated that atypical parkinsonism can be presented in autoimmune encephalitis and paraneoplastic neurological syndromes. However, it is unclear which anti-neural antibodies are involved and when these diseases should be suspected. To address these clinical questions, we conducted a scoping review and analyzed 38 articles. The literature shows that many anti-neural antibodies, including unknown ones, have been reported in progressive supranuclear palsy, corticobasal syndrome, and multiple system atrophy. Moreover, the following symptoms and signs suggest the possibility of autoimmune encephalitis and paraneoplastic neurological syndromes: early onset, acute or subacute progression, the presence of a neoplasm, significant weight loss, abnormal cerebrospinal fluid findings, the absence of typical brain magnetic resonance imaging findings, and the existence of atypical physical examination signs.
最近的研究表明，非典型帕金森症可出现在自身免疫性脑炎和副肿瘤性神经系统综合征中。然而，尚不清楚涉及哪些抗神经抗体以及何时应怀疑这些疾病。为了解决这些临床问题，我们进行了一项范围综述并分析了38篇文章。文献表明，在进行性核上性麻痹、皮质基底节综合征和多系统萎缩中已报告了许多抗神经抗体，包括未知抗体。此外，以下症状和体征提示自身免疫性脑炎和副肿瘤性神经系统综合征的可能性：起病早、急性或亚急性进展、存在肿瘤、显著体重减轻、脑脊液检查结果异常、缺乏典型的脑磁共振成像表现以及存在非典型体格检查体征。
