Pyomyositis is a bacterial infection of skeletal muscle that is usually accompanied by abscess formation. Staphylococcus aureus is the most common causative organism. Pyomyositis should be suspected in any patient who presents with fever, muscle pain and leukocytosis. It is confirmed by needle aspiration and culture of the suspected muscle group. Treatment entails incision and drainage of abscesses and appropriate antibiotic therapy.