Buda A J, Zotz R J
Am Heart J. 1986 Sep;112(3):447-52. doi: 10.1016/0002-8703(86)90504-1.
The effect of abrupt coronary artery occlusion on regional left ventricular (LV) function is well known, but serial changes in circumferential regional function over the first few hours have not been extensively investigated. Circumflex coronary artery occlusion was produced in nine closed-chest, conscious dogs and changes in LV circumferential function were assessed using two-dimensional echocardiography (2DE) performed in the short-axis projection at the mid-papillary muscle level. End-diastolic and end-systolic frames were manually digitized and regional area ejection fractions at 22.5-degree intervals were calculated using a fixed diastolic center of mass. Endocardial motion abnormality was measured from a circumferential regional ejection fraction map. The extent of wall motion abnormality was measured as that exceeding 95% confidence limits of normal controls; the degree of dyssynergy was measured as the planimetered area of the extent of wall motion abnormality. Following circumflex coronary artery occlusion, a wall motion abnormality was well defined with a minute of occlusion and its circumferential extent measured 146 +/- 16 degrees with 11 +/- 2 cm2 absolute degree of dyssynergy. These parameters did not change over the course of the coronary artery occlusion. We conclude that circumferential regional abnormalities produced by coronary occlusions are well defined early and do not change over the first 3 hours of acute ischemia and infarction.
冠状动脉突然闭塞对局部左心室（LV）功能的影响是众所周知的，但在最初几个小时内圆周区域功能的连续变化尚未得到广泛研究。在9只开胸清醒犬身上造成回旋支冠状动脉闭塞，并使用二维超声心动图（2DE）在乳头肌中部水平的短轴投影中评估左心室圆周功能的变化。手动对舒张末期和收缩末期图像进行数字化处理，并使用固定的舒张期质心计算每隔22.5度的区域面积射血分数。从圆周区域射血分数图测量心内膜运动异常。壁运动异常的范围测量为超过正常对照95%置信限的部分；不协调程度测量为壁运动异常范围的平面测量面积。在回旋支冠状动脉闭塞后，闭塞1分钟时壁运动异常就很明显，其圆周范围为146±16度，绝对不协调程度为11±2平方厘米。这些参数在冠状动脉闭塞过程中没有变化。我们得出结论，冠状动脉闭塞产生的圆周区域异常在早期就很明显，并且在急性缺血和梗死的最初3小时内不会改变。
