Department of Pathology and Dermatopathology, Kaiser Permanente, Orange County, Pasadena, California, USA.
Department of Dermatology, Kaiser Permanente, Orange County, Pasadena, California, USA.
J Cutan Pathol. 2023 Oct;50(10):873-877. doi: 10.1111/cup.14499. Epub 2023 Jul 30.
The 2022-2023 mpox outbreak is a global worldwide concern, especially since the virus was previously mainly localized regionally in Central and West Africa. The infection is typically self-limiting and transmitted by close contact/exposure with infected material. Recent cases have been known to present atypically without prodromal symptoms and initially with skin lesions. The histopathology of mpox lesions is rarely reported. Here, we present two middle-aged males presenting initially with painless skin lesions confirmed for mpox by nucleic acid amplification assay. Skin biopsies of the lesion were available for clinicopathologic correlation. Histopathology demonstrated ulceration with viral cytopathologic changes.
2022-2023 年猴痘疫情是一个全球性的关注点，尤其是因为该病毒之前主要局限于中非和西非地区。这种感染通常是自限性的，通过与受感染的材料密切接触/暴露而传播。最近的病例表现为没有前驱症状，最初是皮肤损伤，这并不典型。猴痘病变的组织病理学很少有报道。在这里，我们报告了两名中年男性，他们最初表现为无痛性皮肤损伤，经核酸扩增检测证实为猴痘。皮损的皮肤活检可用于临床病理相关性分析。组织病理学显示溃疡伴病毒细胞病理改变。
