Shademan Behrouz, Avci Cigir Biray, Karamad Vahidreza, Soureh Gholamreza Jahangirzadeh, Olia Jalhe Bagheri Hamzyan, Esmaily Farzaneh, Nourazarian Alireza, Nikanfar Masoud
Department of Medical Biology, Faculty of Medicine, Ege University, 35040 Izmir, Turkey.
Department of Genetics, Tabriz Branch, Islamic Azad University, 43351-14543 Tabriz, Iran.
J Integr Neurosci. 2023 Jul 5;22(4):88. doi: 10.31083/j.jin2204088.
Ischaemic stroke is a sudden neurological disorder caused by localised cerebral ischaemia and persistent cerebral infarction. Occlusion of large arteries due to atherothrombosis, cerebral embolism (i.e., embolic infarction), no thrombotic occlusion in small, deep cerebral arteries (i.e., lacunar infarction), and stenosis of proximal arteries due to hypotension leading to decreased cerebral blood flow in arterial supply zones are the most common causes of ischemic stroke (i.e., hemodynamic stroke). It is now known that organelles play an important role in various signaling events and cellular functions. The molecular mechanisms of mitochondria are involved in cerebral ischemia by generating and scavenging reactive oxygen species, apoptosis, biogenesis, mitochondrial dynamics, and inflammation are all examples of electron transport chain dysfunction. More knowledge about the involvement of mitochondria in ischemia-induced neuronal death and neuronal protection will contribute to the development of better treatment programs for stroke syndromes such as ischemic stroke.
缺血性中风是一种由局部脑缺血和持续性脑梗死引起的突发性神经疾病。动脉粥样硬化血栓形成导致大动脉闭塞、脑栓塞（即栓塞性梗死）、小的深部脑动脉无血栓性闭塞（即腔隙性梗死）以及低血压导致近端动脉狭窄从而引起动脉供血区脑血流量减少，是缺血性中风（即血流动力学性中风）最常见的病因。现在已知细胞器在各种信号转导事件和细胞功能中发挥重要作用。线粒体的分子机制通过产生活性氧和清除活性氧、凋亡、生物发生、线粒体动力学以及炎症参与脑缺血，这些都是电子传递链功能障碍的例子。更多关于线粒体参与缺血诱导的神经元死亡和神经元保护的知识将有助于开发针对缺血性中风等中风综合征的更好治疗方案。
