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胆囊黏液腺癌:急性胆囊炎合并胆结石的偶然发现

Mucinous Adenocarcinoma of Gallbladder: An Incidental Finding of Acute Cholecystitis With Cholelithiasis.

作者信息

Soukhak Fahim, Shugan Tanapong J, Urayeneza Olivier

机构信息

Surgery, Ross University School of Medicine, Los Angeles, USA.

Family Medicine, Doctors Medical Center, Modesto, USA.

出版信息

Cureus. 2023 Jun 28;15(6):e41089. doi: 10.7759/cureus.41089. eCollection 2023 Jun.

DOI:10.7759/cureus.41089
PMID:37519586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10378714/
Abstract

The biliary tract's most frequent malignancy is gallbladder cancer (GBC). Due to the growing number of laparoscopic cholecystectomy procedures, the majority of GBC cases in the United States are diagnosed as incidental findings. Roughly 5% of the reported cases of gallbladder adenocarcinomas are of the mucinous type. Mucinous adenocarcinoma tumors contain more than 50% of mucin materials and are clinically characterized by poor prognosis. Initial presentation can mimic acute cholecystitis or cholelithiasis; meanwhile, histological findings post-cholecystectomy are the main diagnostic criteria of mucinous adenocarcinoma of the gallbladder. This case presents a patient who has been diagnosed with cholelithiasis and cholecystitis and subsequently underwent laparoscopic cholecystectomy. Histopathological examination of the gallbladder specimen was consistent with incidental gallbladder adenocarcinoma, the mucinous subtype to be specific.

摘要

胆道最常见的恶性肿瘤是胆囊癌(GBC)。由于腹腔镜胆囊切除术的数量不断增加,美国大多数GBC病例是在偶然情况下被诊断出来的。在报告的胆囊腺癌病例中,约5%为黏液型。黏液性腺癌肿瘤含有超过50%的黏液物质,临床特征为预后不良。初始表现可类似于急性胆囊炎或胆石症;同时,胆囊切除术后的组织学检查结果是胆囊黏液性腺癌的主要诊断标准。本病例介绍了一名被诊断为胆石症和胆囊炎并随后接受腹腔镜胆囊切除术的患者。胆囊标本的组织病理学检查结果与偶然发现的胆囊腺癌一致,具体为黏液性亚型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0c5/10378714/9bdb12d8289d/cureus-0015-00000041089-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0c5/10378714/b6a41cc52b9c/cureus-0015-00000041089-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0c5/10378714/9f0e08ea2d7c/cureus-0015-00000041089-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0c5/10378714/9bdb12d8289d/cureus-0015-00000041089-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0c5/10378714/b6a41cc52b9c/cureus-0015-00000041089-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0c5/10378714/9f0e08ea2d7c/cureus-0015-00000041089-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0c5/10378714/9bdb12d8289d/cureus-0015-00000041089-i03.jpg

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本文引用的文献

1
Mucinous Adenocarcinoma of Gallbladder Presenting As Acute Calculous Cholecystitis.表现为急性结石性胆囊炎的胆囊黏液腺癌
Cureus. 2021 Apr 18;13(4):e14548. doi: 10.7759/cureus.14548.
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Neoadjuvant chemotherapy with gemcitabine plus cisplatin followed by radical liver resection versus immediate radical liver resection alone with or without adjuvant chemotherapy in incidentally detected gallbladder carcinoma after simple cholecystectomy or in front of radical resection of BTC (ICC/ECC) - a phase III study of the German registry of incidental gallbladder carcinoma platform (GR)- the AIO/ CALGP/ ACO- GAIN-trial.新辅助化疗联合吉西他滨和顺铂后根治性肝切除术与单纯胆囊切除术后或根治性 BTC 切除术前单纯根治性肝切除术或辅助化疗与或不辅助化疗在偶然发现的胆囊癌中的比较(ICC/ECC) - 德国偶然发现的胆囊癌平台(GR)登记处的 III 期研究- AIO/CALGP/ACO-GAIN 试验。
BMC Cancer. 2020 Feb 14;20(1):122. doi: 10.1186/s12885-020-6610-4.
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Evaluation and management of incidental gallbladder cancer.胆囊意外癌的评估与处理
Chin Clin Oncol. 2019 Aug;8(4):37. doi: 10.21037/cco.2019.07.01. Epub 2019 Aug 5.
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Analysis of wedge resection of gallbladder bed and lymphadenectomy on adequate oncologic clearance for gallbladder cancer.胆囊床楔形切除术及淋巴结清扫术对胆囊癌充分肿瘤清除的分析
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World J Gastroenterol. 2015 Nov 21;21(43):12211-7. doi: 10.3748/wjg.v21.i43.12211.
6
[Incidental T1b-T3 gallbladder carcinoma. Extended cholecystectomy as an underestimated prognostic factor-results of the German registry].[偶然发现的T1b - T3期胆囊癌。扩大胆囊切除术作为一个被低估的预后因素——德国登记处的结果]
Chirurg. 2014 Feb;85(2):131-8. doi: 10.1007/s00104-013-2587-8.
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[Immediate radical re-resection of incidental T1b  gallbladder cancer and the problem of an adequate extent of resection (results of the German Registry "Incidental Gallbladder Cancer")].[意外发现的T1b期胆囊癌的即刻根治性再次切除术及切除范围是否足够的问题(德国“意外胆囊癌”登记研究结果)]
Zentralbl Chir. 2014 Dec;139 Suppl 2:e43-8. doi: 10.1055/s-0030-1262698. Epub 2011 Mar 1.
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National trends in the management and survival of surgically managed gallbladder adenocarcinoma over 15 years: a population-based analysis.15 年以上手术治疗胆囊腺癌的管理和生存的国家趋势:基于人群的分析。
J Gastrointest Surg. 2010 Oct;14(10):1578-91. doi: 10.1007/s11605-010-1335-3. Epub 2010 Sep 8.
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Gallbladder cancer: comparison of patients presenting initially for definitive operation with those presenting after prior noncurative intervention.胆囊癌:初次接受根治性手术的患者与先前接受非根治性干预后就诊的患者的比较。
Ann Surg. 2000 Oct;232(4):557-69. doi: 10.1097/00000658-200010000-00011.