Bailey George, Trivedi Jaya R
Neurology, University of Texas (UT) Southwestern Medical Center, Dallas, USA.
Cureus. 2023 Jun 26;15(6):e41005. doi: 10.7759/cureus.41005. eCollection 2023 Jun.
Peripheral nerve hyperexcitability is a rare disorder characterized by spontaneous motor unit activity. Although peripheral nerve hyperexcitability is seen in multiple immune-mediated neurological conditions, an association with dermatomyositis has rarely been reported. We present a 65-year-old woman with serological and muscle biopsy features of dermatomyositis who also developed marked muscle hypertrophy, stiffness, and delayed relaxation along with electrodiagnostic features of peripheral nerve hyperexcitability such as that seen in Isaacs syndrome.
周围神经兴奋性增高是一种以自发性运动单位活动为特征的罕见疾病。虽然周围神经兴奋性增高可见于多种免疫介导的神经系统疾病，但与皮肌炎的关联鲜有报道。我们报告了一名65岁女性，她具有皮肌炎的血清学和肌肉活检特征，同时还出现了明显的肌肉肥大、僵硬和延迟松弛，以及周围神经兴奋性增高的电诊断特征，如艾萨克斯综合征所见。
