糖尿病的存在进一步增加了乙型或丙型肝炎病毒相关性肝硬化患者患肝细胞癌的风险：一项荟萃分析。
Presence of diabetes further heightens hepatocellular carcinoma risk in patients with hepatitis B or hepatitis C virus-related cirrhosis: A meta-analysis.
作者信息
Zang Ye, Xu Wei, Qiu Yue, Jiang Xiaomeng, Fan Yu
机构信息
Department of Oncology, The People's Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Danyang, Jiangsu Province, 212300, China.
Cancer Institute, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, Jiangsu, 212300, China.
出版信息
Heliyon. 2023 Jul 19;9(8):e18425. doi: 10.1016/j.heliyon.2023.e18425. eCollection 2023 Aug.
OBJECTIVE
Impact of diabetes mellitus on the development of hepatocellular carcinoma (HCC) remained controversial in cirrhotic patients. This meta-analysis aimed to investigate the association of diabetes and the occurrence of HCC in patients with hepatitis B or hepatitis C virus-related cirrhosis.
METHODS
Two authors comprehensively searched PubMed and Embase databases until June 22, 2023, to identify studies that evaluated the association of diabetes with the occurrence of HCC in patients with hepatitis B or hepatitis C virus-related cirrhosis.
RESULTS
Sixteen retrospective/prospective cohort studies reporting on 15 articles (5357 cirrhotic patients) were included. The prevalence of diabetes in hepatitis B and hepatitis C virus-related cirrhosis patients ranged from 4 to 46%. Diabetes was associated with higher risk of HCC (risk ratio [RR] 1.74; 95% confidence intervals [CI] 1.24-2.45) in patients with hepatitis C virus-related cirrhosis. However, no significant relationship of diabetes with the occurrence of HCC was present in studies with less than 48-month follow-up among patients with hepatitis C virus-related cirrhosis (RR 1.28; 95% CI 0.68-2.43). Moreover, diabetes also conferred an increased risk of HCC (RR 2.67; 95% CI 2.03-3.51) in patients with hepatitis B virus-related cirrhosis.
CONCLUSION
Presence of diabetes significantly predicted the occurrence of HCC in patients with hepatitis B or hepatitis C virus-related cirrhosis.
目的
糖尿病对肝硬化患者肝细胞癌（HCC）发生发展的影响仍存在争议。本荟萃分析旨在探讨糖尿病与乙型或丙型肝炎病毒相关肝硬化患者发生HCC之间的关联。
方法
两位作者全面检索了截至2023年6月22日的PubMed和Embase数据库，以确定评估糖尿病与乙型或丙型肝炎病毒相关肝硬化患者发生HCC之间关联的研究。
结果
纳入了16项回顾性/前瞻性队列研究，这些研究发表在15篇文章中（共5357例肝硬化患者）。乙型和丙型肝炎病毒相关肝硬化患者的糖尿病患病率在4%至46%之间。在丙型肝炎病毒相关肝硬化患者中，糖尿病与HCC的较高风险相关（风险比[RR]1.74；95%置信区间[CI]1.24 - 2.45）。然而，在丙型肝炎病毒相关肝硬化患者中随访时间少于48个月的研究中，糖尿病与HCC的发生无显著关系（RR 1.28；95% CI 0.68 - 2.43）。此外，在乙型肝炎病毒相关肝硬化患者中，糖尿病也增加了HCC的风险（RR 2.67；95% CI 2.03 - 3.51）。
结论
糖尿病的存在显著预测了乙型或丙型肝炎病毒相关肝硬化患者发生HCC的情况。
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