A Study of Comparison and Evaluation of Various Intralesional Therapies in Cutaneous Warts.

BACKGROUND

The study compares the efficacy of four immunotherapeutic agents, measles mumps and rubella (MMR), purified protein derivative (PPD), extract, and vitamin D3, in the treatment of multiple cutaneous warts.

AIM AND OBJECTIVES

To observe the clinical responses and safety of different intralesional immunotherapeutic agents and compare their efficacy.

MATERIALS AND METHODS

Hundred patients with multiple (>5) cutaneous warts were enrolled in the study and randomized into four groups: Group A: MMR, Group B: PPD, Group C: extract, and Group D: Vitamin D. Target wart was selected, and the intralesional injections were given at three weekly intervals for a maximum of three doses. Response was observed in target and distant warts three months after the last injection.

RESULTS

Intralesional vitamin D3 had the highest efficacy, while MMR had the lowest efficacy in clearance of target wart. Intralesional extract had the highest efficacy, while vitamin D3 had the lowest efficacy in clearance of distant warts. Intralesional was the most effective treatment for both local and distant warts. Side effects were minimal and transitory in nature.

CONCLUSION

Intralesional immunotherapy is a safe, affordable, and efficacious treatment for warts.