Chaudhary Malay, Brar Arwinder, Agarwal Pooja, Chavda Vruti, Jagati Ashish, Rathod Santoshdev P
Department of Dermatology, Smt. Shardaben General Hospital, Saraspur, Gujarat, India.
Department of Dermatology, S.V.P. Hospital, Near Ellis-Bridge, Paladi, Ahmedabad, Gujarat, India.
Indian Dermatol Online J. 2023 Jun 28;14(4):487-492. doi: 10.4103/idoj.idoj_492_22. eCollection 2023 Jul-Aug.
The study compares the efficacy of four immunotherapeutic agents, measles mumps and rubella (MMR), purified protein derivative (PPD), extract, and vitamin D3, in the treatment of multiple cutaneous warts.
To observe the clinical responses and safety of different intralesional immunotherapeutic agents and compare their efficacy.
Hundred patients with multiple (>5) cutaneous warts were enrolled in the study and randomized into four groups: Group A: MMR, Group B: PPD, Group C: extract, and Group D: Vitamin D. Target wart was selected, and the intralesional injections were given at three weekly intervals for a maximum of three doses. Response was observed in target and distant warts three months after the last injection.
Intralesional vitamin D3 had the highest efficacy, while MMR had the lowest efficacy in clearance of target wart. Intralesional extract had the highest efficacy, while vitamin D3 had the lowest efficacy in clearance of distant warts. Intralesional was the most effective treatment for both local and distant warts. Side effects were minimal and transitory in nature.
Intralesional immunotherapy is a safe, affordable, and efficacious treatment for warts.
本研究比较了四种免疫治疗药物，即麻疹腮腺炎风疹（MMR）、结核菌素纯蛋白衍生物（PPD）、提取物和维生素D3，在治疗多发性皮肤疣方面的疗效。
观察不同皮损内免疫治疗药物的临床反应和安全性，并比较它们的疗效。
一百例患有多发性（>5个）皮肤疣的患者被纳入研究，并随机分为四组：A组：MMR；B组：PPD；C组：提取物；D组：维生素D。选择目标疣，每隔一周进行一次皮损内注射，最多注射三剂。在最后一次注射三个月后观察目标疣和远处疣的反应。
皮损内注射维生素D3在清除目标疣方面疗效最高，而MMR疗效最低。皮损内注射提取物在清除远处疣方面疗效最高，而维生素D3疗效最低。皮损内注射对局部和远处疣都是最有效的治疗方法。副作用轻微且为一过性。
皮损内免疫疗法是一种安全、经济且有效的疣治疗方法。
