Clouse R E, Eckert T C, Staiano A
Am J Med. 1986 Sep;81(3):447-50. doi: 10.1016/0002-9343(86)90297-4.
The relationship of hiatus hernia to esophageal motility pattern was examined in patients referred for evaluation of esophageal symptoms. Results from standard esophageal motility studies were compared with findings on barium radiography of the upper gastrointestinal tract. Of 169 patients without radiographic evidence of esophagitis, 53 (31 percent) had normal motility of the esophageal body, whereas 116 (69 percent) demonstrated esophageal contraction abnormalities, a classification that includes the pattern of diffuse esophageal spasm at the severest extreme. Hiatus hernia was significantly more common in those with contraction abnormalities (25 percent) than in those with normal patterns (8 percent) (p = 0.01). Hiatus hernia increased in prevalence with increasing severity of contraction abnormalities, such that hiatus hernia was present in nearly half of patients with the pattern typifying diffuse esophageal spasm. Thus, hiatus hernia and esophageal contraction abnormalities are associated once other associations with hiatus hernia (e.g., esophagitis and scleroderma) have been excluded. These findings may help explain the recognized relationship of esophageal symptoms to hiatus hernia in patients without significant gastroesophageal reflux.
在因食管症状接受评估的患者中,研究了食管裂孔疝与食管动力模式之间的关系。将标准食管动力研究的结果与上消化道钡剂造影的结果进行了比较。在169例无食管炎放射学证据的患者中,53例(31%)食管体部动力正常,而116例(69%)表现出食管收缩异常,这一分类在最严重的极端情况下包括弥漫性食管痉挛模式。食管裂孔疝在收缩异常患者中(25%)比在动力正常患者中(8%)明显更常见(p = 0.01)。食管裂孔疝的患病率随着收缩异常严重程度的增加而增加,以至于在几乎一半具有弥漫性食管痉挛典型模式的患者中存在食管裂孔疝。因此,一旦排除了与食管裂孔疝的其他关联(如食管炎和硬皮病),食管裂孔疝与食管收缩异常是相关的。这些发现可能有助于解释在无明显胃食管反流的患者中,食管症状与食管裂孔疝之间已被认可的关系。