Nguyen Henry H, Swain Mark G
University of Calgary Liver Unit, Departments of Medicine and Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
University of Calgary Liver Unit, Department of Medicine, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Front Neurosci. 2023 Jul 13;17:1171253. doi: 10.3389/fnins.2023.1171253. eCollection 2023.
Symptoms of fatigue, social withdrawal and mood disturbances are commonly encountered in patients with chronic liver disease and have a detrimental effect on patient quality of life. Treatment options for these symptoms are limited and a current area of unmet medical need. In this review, we will evaluate the potential mechanistic avenues within the gut-liver-brain axis that may be altered in the setting of chronic liver disease that drive the development of these symptoms. Both clinical and pre-clinical studies will be highlighted as we discuss how perturbations in host immune response, microbiome, neural responses, and metabolites composition can affect the central nervous system.
疲劳、社交退缩和情绪障碍症状在慢性肝病患者中很常见，对患者生活质量有不利影响。这些症状的治疗选择有限，是当前未满足的医疗需求领域。在本综述中，我们将评估肠道-肝脏-脑轴内可能在慢性肝病背景下发生改变的潜在机制途径，这些途径会促使这些症状的发展。在我们讨论宿主免疫反应、微生物群、神经反应和代谢物组成的扰动如何影响中枢神经系统时，将重点介绍临床和临床前研究。
