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Gemini Amphiphiles: Robust Cytosolic Delivery of Therapeutic Biomacromolecules through Non-Endocytic Translocation Pathways.

作者信息

Zhao Yu, Wich Douglas, Xu Qiaobing

机构信息

Department of Biomedical Engineering, Tufts University, Medford, Massachusetts 02155, United States.

出版信息

ACS Cent Sci. 2023 Jul 7;9(7):1266-1268. doi: 10.1021/acscentsci.3c00793. eCollection 2023 Jul 26.

DOI:10.1021/acscentsci.3c00793
PMID:37521797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10375569/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc56/10375569/3ba5beb8701a/oc3c00793_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc56/10375569/609cf48e6031/oc3c00793_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc56/10375569/3ba5beb8701a/oc3c00793_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc56/10375569/609cf48e6031/oc3c00793_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc56/10375569/3ba5beb8701a/oc3c00793_0002.jpg

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本文引用的文献

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2
The role of lipid components in lipid nanoparticles for vaccines and gene therapy.脂质成分在疫苗和基因治疗用脂质纳米粒中的作用。
Adv Drug Deliv Rev. 2022 Sep;188:114416. doi: 10.1016/j.addr.2022.114416. Epub 2022 Jul 3.
3
Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics.
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Nat Chem. 2022 Mar;14(3):274-283. doi: 10.1038/s41557-021-00854-4. Epub 2022 Feb 3.
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Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy.胆固醇耗竭导致癌细胞变硬，从而增强过继性 T 细胞免疫疗法。
Nat Biomed Eng. 2021 Dec;5(12):1411-1425. doi: 10.1038/s41551-021-00826-6. Epub 2021 Dec 6.
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Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19.新冠病毒mRNA-1273疫苗第二剂接种后6个月的抗体持久性
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Antibody response to first BNT162b2 dose in previously SARS-CoV-2-infected individuals.既往感染过严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的个体对第一剂BNT162b2的抗体反应。
Lancet. 2021 Mar 20;397(10279):1057-1058. doi: 10.1016/S0140-6736(21)00501-8. Epub 2021 Feb 25.
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Lipid-Raft-Mediated Direct Cytosolic Delivery of Polymer-Coated Soft Nanoparticles.脂质筏介导的聚合物包被软纳米颗粒的细胞质直接递送。
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