Ludwig Cancer Institute, Nuffield Department of Medicine, Old Road Campus Research Building, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, UK.
MRC Human Genetics Unit, CRUK Scotland Centre and Edinburgh Cancer Research, Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH42XU, UK.
Dis Model Mech. 2023 Aug 1;16(8). doi: 10.1242/dmm.050351. Epub 2023 Jul 31.
Modelling adult diseases to understand their aetiology and progression, and to develop new therapies, is a major challenge for medical biology. We are excited by new efforts in the zebrafish community to develop models of adult diseases that range from cancer to heart, infectious and age-related diseases, and those that relate to toxicology and complex social behaviours. Here, we discuss some of the advances in the field of zebrafish models of adult disease, and where we see opportunities and challenges ahead.
模拟成人疾病以了解其病因和进展，并开发新的治疗方法，是医学生物学面临的主要挑战。我们对斑马鱼研究社区在开发从癌症到心脏、传染病和与年龄相关的疾病，以及与毒理学和复杂社会行为相关的成年疾病模型方面所做的新努力感到兴奋。在这里，我们讨论了该领域的一些进展，以及我们认为未来的机会和挑战。
