Department of Neurobiology and Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Neurosci Bull. 2023 Nov;39(11):1683-1702. doi: 10.1007/s12264-023-01083-0. Epub 2023 Jul 31.
Parvalbumin interneurons belong to the major types of GABAergic interneurons. Although the distribution and pathological alterations of parvalbumin interneuron somata have been widely studied, the distribution and vulnerability of the neurites and fibers extending from parvalbumin interneurons have not been detailly interrogated. Through the Cre recombinase-reporter system, we visualized parvalbumin-positive fibers and thoroughly investigated their spatial distribution in the mouse brain. We found that parvalbumin fibers are widely distributed in the brain with specific morphological characteristics in different regions, among which the cortex and thalamus exhibited the most intense parvalbumin signals. In regions such as the striatum and optic tract, even long-range thick parvalbumin projections were detected. Furthermore, in mouse models of temporal lobe epilepsy and Parkinson's disease, parvalbumin fibers suffered both massive and subtle morphological alterations. Our study provides an overview of parvalbumin fibers in the brain and emphasizes the potential pathological implications of parvalbumin fiber alterations.
钙结合蛋白阳性中间神经元属于 GABA 能中间神经元的主要类型。尽管已经广泛研究了钙结合蛋白阳性中间神经元胞体的分布和病理改变，但延伸自钙结合蛋白阳性中间神经元的轴突和纤维的分布和易损性尚未被详细研究。通过 Cre 重组酶报告系统，我们可视化了钙结合蛋白阳性纤维，并彻底研究了它们在小鼠大脑中的空间分布。我们发现钙结合蛋白纤维在大脑中广泛分布，在不同区域具有特定的形态特征，其中皮层和丘脑表现出最强的钙结合蛋白信号。在纹状体和视束等区域，甚至检测到长程厚的钙结合蛋白投射。此外，在颞叶癫痫和帕金森病的小鼠模型中，钙结合蛋白纤维经历了大量和微妙的形态改变。我们的研究提供了大脑中钙结合蛋白纤维的概述，并强调了钙结合蛋白纤维改变的潜在病理意义。
