血清核黄素和黄素单核苷酸与胰腺癌的关系：一项前瞻性队列研究的结果。
The Association Between Serum Riboflavin and Flavin Mononucleotide With Pancreatic Cancer: Findings From a Prospective Cohort Study.
机构信息
From the UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA.
Bevital A/S, Bergen, Norway.
出版信息
Pancreas. 2023 Feb 1;52(2):e127-e134. doi: 10.1097/MPA.0000000000002220.
OBJECTIVES
Vitamin B2 (riboflavin) has a prime role in metabolic reactions imperative to cell cycle and proliferation. We investigated the associations between serum concentrations of riboflavin flavin mononucleotide with the risk of pancreatic cancer in a nested case-control study involving 58 cases and 104 matched controls.
METHODS
The Singapore Chinese Health Study, an ongoing prospective cohort study of 63,257 Chinese Singaporeans. Conditional logistic regression method was used to evaluate these associations with adjustment for potential confounders including the level of education, body mass index, smoking status, alcohol consumption, history of diabetes, serum cotinine and pyridoxal 5'-phosphate, estimated glomerular filtration rate, and total methyl donors (ie, the sum of serum choline, betaine, and methionine).
RESULTS
The risk of pancreatic cancer increased with increasing level of serum riboflavin in a dose-dependent manner, especially in men (Ptrend = 0.003). The odds ratio (95% confidence intervals) of pancreatic cancer for the second and third tertiles of serum riboflavin, compared with the lowest tertile, were 9.92 (1.65-59.77) and 25.59 (3.09-212.00), respectively. This positive association was stronger in individuals with a longer follow-up period (≥7 years).
CONCLUSIONS
The findings suggest a potential role of riboflavin in the development of pancreatic cancer, especially in men.
目的
维生素 B2（核黄素）在细胞周期和增殖所必需的代谢反应中起着重要作用。我们在一项巢式病例对照研究中调查了血清核黄素黄素单核苷酸浓度与胰腺癌风险之间的关联，该研究纳入了 58 例病例和 104 例匹配对照。
方法
新加坡华人健康研究是一项正在进行的 63257 名新加坡华人的前瞻性队列研究。采用条件逻辑回归方法，在调整了包括教育程度、体重指数、吸烟状况、饮酒状况、糖尿病史、血清可替宁和吡哆醛 5'-磷酸、估计肾小球滤过率以及总甲基供体（即血清胆碱、甜菜碱和蛋氨酸的总和）等潜在混杂因素后，评估这些关联。
结果
血清核黄素水平与胰腺癌风险呈剂量依赖性增加，尤其是在男性中（趋势 P 值=0.003）。与最低三分位相比，血清核黄素第二和第三三分位的胰腺癌比值比（95%置信区间）分别为 9.92（1.65-59.77）和 25.59（3.09-212.00）。在随访时间较长（≥7 年）的个体中，这种正相关关系更强。
结论
这些发现提示核黄素在胰腺癌的发生发展中可能具有潜在作用，尤其是在男性中。
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