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Genetic drivers in the natural history of chronic lymphocytic leukemia development as early as 16 years before diagnosis.

作者信息

Kolijn P Martijn, Späth Florentin, Khouja Mouhamad, Hengeveld Paul J, van der Straten Lina, Darzentas Nikos, Hultdin Magnus, McKay James D, Pott Christiane, Vermeulen Roel C H, Langerak Anton W

机构信息

Department of Immunology, Laboratory Medical Immunology, Erasmus MC, Rotterdam, The Netherlands.

Division of Environmental Epidemiology and Veterinary Public Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.

出版信息

Blood. 2023 Oct 19;142(16):1399-1403. doi: 10.1182/blood.2023019609.

DOI:10.1182/blood.2023019609
PMID:37523714
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10651867/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be27/10651867/bf10915624d3/BLOOD_BLD-2023-019609-gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be27/10651867/533f5b09406b/BLOOD_BLD-2023-019609-ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be27/10651867/5024113b87d4/BLOOD_BLD-2023-019609-gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be27/10651867/bf10915624d3/BLOOD_BLD-2023-019609-gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be27/10651867/533f5b09406b/BLOOD_BLD-2023-019609-ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be27/10651867/5024113b87d4/BLOOD_BLD-2023-019609-gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be27/10651867/bf10915624d3/BLOOD_BLD-2023-019609-gr2.jpg

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Blood Cancer J. 2022 Mar 30;12(3):49. doi: 10.1038/s41408-022-00650-4.
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High-risk subtypes of chronic lymphocytic leukemia are detectable as early as 16 years prior to diagnosis.高危亚型慢性淋巴细胞白血病早在诊断前 16 年即可检测到。
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