通过钯催化异腈插入2-氮杂环丙烷合成多取代嘧啶
Synthesis of Polysubstituted Pyrimidines through Palladium-Catalyzed Isocyanide Insertion to 2-Azirines.
作者信息
Saeifard Leyla, Amiri Kamran, Rominger Frank, Müller Thomas J J, Balalaie Saeed
机构信息
Peptide Chemistry Research Institute, K. N. Toosi University of Technology, P.O. Box 15875-4416, Tehran, Iran.
Organisch-Chemisches Institut der Universität Heidelberg, Im Neuenheimer Feld 271, D-69120 Heidelberg, Germany.
出版信息
J Org Chem. 2023 Sep 1;88(17):12519-12525. doi: 10.1021/acs.joc.3c01248. Epub 2023 Jul 31.
The domino process of the palladium-catalyzed coupling reaction of isocyanides with 2-azirine provides various tetrasubstituted pyrimidines via one C-C bond and two C-N bond formations with satisfactory yields. The title compounds are obtained with good functional group tolerance, high atom economy, and broad substrate scopes.
异腈与2-氮杂环丙烯的钯催化偶联反应的多米诺过程通过形成一个C-C键和两个C-N键，以令人满意的产率提供了各种四取代嘧啶。所得到的标题化合物具有良好的官能团耐受性、高原子经济性和广泛的底物范围。
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