钌催化 2H-氮丙啶与炔烃的 [3 + 2] 环加成反应：构建多取代吡咯。
Ruthenium-Catalyzed [3 + 2] Cycloaddition of 2H-Azirines with Alkynes: Access to Polysubstituted Pyrroles.
机构信息
Dalian Institute of Chemical Physics, Chinese Academy of Sciences , 457 Zhongshan Road, Dalian 116023, China.
University of Chinese Academy of Sciences , Beijing 100049, China.
出版信息
J Org Chem. 2016 Dec 2;81(23):12031-12037. doi: 10.1021/acs.joc.6b02322. Epub 2016 Nov 17.
A ruthenium-catalyzed intermolecular [3 + 2] cycloaddition of 2H-azirines and activated alkynes is reported, which provides polysubstituted pyrroles in moderate to good yields. This approach features a C-N bond cleavage of 2H-azirines by a ruthenium catalyst. The results of this study would provide a complementary method to synthesize polysubstituted pyrroles from the known 2H-azirine approaches and advance 2H-azirine chemistry.
报道了一种钌催化的 2H-氮丙啶与活化炔烃的分子间[3+2]环加成反应，该反应以中等至良好的收率得到多取代吡咯。该方法通过钌催化剂实现了 2H-氮丙啶的 C-N 键断裂。该研究结果为从已知的 2H-氮丙啶方法合成多取代吡咯提供了一种补充方法，并推进了 2H-氮丙啶化学的发展。
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