Department of Gynaecology, First People's Hospital of Jiashan County, Jiaxing, Zhejiang Province, China.
Gynecol Endocrinol. 2023 Dec;39(1):2239934. doi: 10.1080/09513590.2023.2239934.
Though recent studies have pointed out different manifestations between obese and nonobese patients with polycystic ovarian syndrome (PCOS), there is no clear evidence to confirm this viewpoint. Therefore, the metabolic characteristics of obese and nonobese patients with PCOS were systematically compared through meta-analysis in this study.
Data were searched from PubMed, Web of Science, Embase, Cochrane Library, CNKI, and Wanfang databases. Articles on obese and nonobese patients with PCOS published from database inception to January 2022 were included. Meta-analysis was performed using Stata 16.0 statistical software.
A total of 739 articles were initially retrieved, and ultimately 14 studies were involved in the meta-analysis. Specifically, there were 801 patients in the observation group (obese patients with PCOS) and 925 patients in the control group (nonobese patients with PCOS). Compared with the control group, the observation group had significantly lower levels of sex hormone-binding globulin (SHBG), high-density lipoprotein (HDL), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and higher levels of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL). Nevertheless, there were no significant differences between the two groups in systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose, and testosterone.
Compared with nonobese patients with PCOS, obese patients with PCOS have worse blood lipid parameters and lower levels of LH and FSH. Also, there are significant differences in metabolic characteristics between the two groups of patients. Most importantly, our findings provide guidance for the clinical diagnosis and treatment of PCOS.
尽管最近的研究指出肥胖和非肥胖多囊卵巢综合征（PCOS）患者之间存在不同的表现，但尚无明确证据证实这一观点。因此，本研究通过荟萃分析系统比较了肥胖和非肥胖 PCOS 患者的代谢特征。
从 PubMed、Web of Science、Embase、Cochrane Library、CNKI 和万方数据库中检索数据。纳入从数据库建立到 2022 年 1 月发表的关于肥胖和非肥胖 PCOS 患者的文章。使用 Stata 16.0 统计软件进行荟萃分析。
共初检到 739 篇文章，最终纳入 14 项研究进行荟萃分析。具体来说，观察组（肥胖 PCOS 患者）有 801 例，对照组（非肥胖 PCOS 患者）有 925 例。与对照组相比，观察组的性激素结合球蛋白（SHBG）、高密度脂蛋白（HDL）、黄体生成素（LH）、卵泡刺激素（FSH）水平明显较低，总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白（LDL）水平较高。然而，两组间的收缩压（SBP）、舒张压（DBP）、血糖和睾酮水平无显著差异。
与非肥胖 PCOS 患者相比，肥胖 PCOS 患者的血脂参数更差，LH 和 FSH 水平更低。此外，两组患者的代谢特征存在显著差异。最重要的是，我们的研究结果为 PCOS 的临床诊断和治疗提供了指导。
