便秘与孤立性快速眼动睡眠行为障碍认知和运动能力加速下降有关。
Constipation is linked to accelerated cognitive and motor decline in isolated REM sleep behavior disorder.
机构信息
Department of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea.
Department of Nuclear Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea.
出版信息
Parkinsonism Relat Disord. 2024 Feb;119:105775. doi: 10.1016/j.parkreldis.2023.105775. Epub 2023 Jul 26.
INTRODUCTION
Constipation is associated with higher clinical severity and predicts cognitive decline in Parkinson's disease (PD). Whether the non-motor marker is associated with unfavorable motor and cognitive trajectories from the prodromal stage remains unclear.
METHODS
In a longitudinal prospective cohort of subjects with isolated REM sleep behavior disorders (iRBD), subjects underwent repeated MDS-UPDRS and Mini-Mental Status Examination (MMSE) assessments. Generalized-estimating-equations (GEE) regression model was used to compare the time-dependent trajectories of MDS-UPDRS-III and MMSE scores between subjects with and without constipation at baseline.
RESULTS
Twenty-nine subjects with constipation at baseline (iRBD+constipation) and 24 without (iRBD-constipation) were followed over 4.085 ± 2.645 years. The iRBD+constipation group presented faster decline of both MDS-UPDRS-III and MMSE scores, with additional estimated annual progression of +1.242 and -0.713 points, respectively, compared to the iRBD-constipation group (time*group p < 0.05).
CONCLUSION
Constipation in isolated RBD is associated with accelerated progression of cognitive impairment and motor symptoms.
简介
便秘与帕金森病（PD）的更高临床严重程度相关，并可预测认知能力下降。非运动标志物是否与前驱期的不利运动和认知轨迹相关仍不清楚。
方法
在 REM 睡眠行为障碍（iRBD）孤立的纵向前瞻性队列中，对受试者进行了多次 MDS-UPDRS 和 Mini-Mental 状态检查（MMSE）评估。使用广义估计方程（GEE）回归模型比较基线时存在和不存在便秘的受试者 MDS-UPDRS-III 和 MMSE 评分的时间依赖性轨迹。
结果
29 名基线时有便秘的受试者（iRBD+便秘）和 24 名无便秘的受试者（iRBD-便秘）随访了 4.085±2.645 年。与 iRBD-便秘组相比，iRBD+便秘组的 MDS-UPDRS-III 和 MMSE 评分下降更快，分别估计每年进展+1.242 和-0.713 分（时间*组 p<0.05）。
结论
孤立性 RBD 中的便秘与认知障碍和运动症状的加速进展相关。
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