Ellmauer S, Brandt L
Anaesthesist. 1986 Jul;35(7):414-8.
We studied the effects of thiopentone (3 vs 6 mg/kg) and methohexitone (1 vs 2 mg/kg) on TPR during hypertensive episodes (m BP greater than 80 mmHg) under the conditions of ECC and hypothermia: T led to an initial shortlasting increase of TPR up to 114% and 125% from baseline for the dosages tested. This was followed by a decrease to 67% and 56% respectively. After 5 min TPR returned to control. The effect of M on TPR is less pronounced (maximum reduction of 35%) but of longer duration. In contrast to thiopentone we did not observe a biphasic course of TPR following administration of methohexitone.
我们研究了在体外循环（ECC）和低温条件下，硫喷妥钠（3毫克/千克与6毫克/千克）和甲己炔巴比妥（1毫克/千克与2毫克/千克）对高血压发作期间（平均血压大于80毫米汞柱）总外周阻力（TPR）的影响：硫喷妥钠导致TPR最初短暂升高，在所测试剂量下分别比基线升高至114%和125%。随后分别降至67%和56%。5分钟后TPR恢复至对照水平。甲己炔巴比妥对TPR的影响不太明显（最大降低35%），但持续时间更长。与硫喷妥钠不同，给予甲己炔巴比妥后，我们未观察到TPR的双相变化过程。
