Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Department of Urology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Mol Biol Rep. 2023 Sep;50(9):7867-7877. doi: 10.1007/s11033-023-08689-7. Epub 2023 Jul 31.
Urothelial bladder carcinoma (UC) ranks among the top ten most commonly diagnosed cancers worldwide on an annual basis. The standardized classification system for urothelial bladder tumors is the Tumor, Node, Metastasis classification, which reflects differences between non-muscle-invasive bladder carcinoma (NMIBC) and muscle-invasive bladder carcinoma (MIBC) and it depends on the extent to which tumor has infiltrated the bladder wall and other tissues and organs. NMIBC and MIBC exhibit great intrinsic heterogeneity regarding different prognoses, survival, progression, and treatment outcomes. In recent years, studies based on mRNA expression profiling revealed the existence of biologically relevant molecular subtypes of UC, which show variant molecular features that can provide more precise stratification of UC patients. Here, we present a complex classification of UC based on mRNA expression studies and molecular subtypes of NMIBC and MIBC in detail with regard to different mRNA expression profiles, mutational signatures, and infiltration by non-tumor cells. The possible impact of molecular subtyping on treatment decisions and patients' outcomes is outlined, too.
尿路上皮膀胱癌 (UC) 是全球每年十大最常见癌症之一。尿路上皮肿瘤的标准化分类系统是肿瘤、淋巴结、转移 (TNM) 分类，它反映了非肌肉浸润性膀胱癌 (NMIBC) 和肌肉浸润性膀胱癌 (MIBC) 之间的差异，取决于肿瘤浸润膀胱壁和其他组织和器官的程度。NMIBC 和 MIBC 在不同的预后、生存、进展和治疗结果方面具有很大的内在异质性。近年来，基于 mRNA 表达谱的研究揭示了 UC 存在具有生物学相关性的分子亚型，这些亚型具有不同的分子特征，可以更精确地对 UC 患者进行分层。在这里，我们详细介绍了基于 mRNA 表达研究的 UC 复杂分类，以及 NMIBC 和 MIBC 的分子亚型，涉及不同的 mRNA 表达谱、突变特征和非肿瘤细胞浸润。还概述了分子分型对治疗决策和患者预后的可能影响。
