Pediatric Hematology and Oncology Unit, ARNAS Ospedali Civico.
Emergency Department, ARNAS Ospedali Civico, Di Cristina e Benfratelli.
J Pediatr Hematol Oncol. 2023 Nov 1;45(8):e993-e995. doi: 10.1097/MPH.0000000000002734. Epub 2023 Jul 26.
Hemolytic anemia could be caused by several conditions, depending on intrinsic or extrinsic defects of the erythrocyte. The latter group includes mechanical intravascular hemolysis, generally related to malfunctioning prosthetic heart valves or, rarely, heart valves repair. We describe a case of a child with Down syndrome, who developed hemolytic anemia after mitral valve repair. We observed that this condition is a rare complication in pediatrics, with only 7 cases reported in literature. Mechanical hemolysis should always be considered in the differential diagnosis of a new-onset hemolytic anemia, especially in patients with valvular heart disease, undergoing cardiac surgery.
溶血性贫血可由多种原因引起，这取决于红细胞的内在或外在缺陷。后者包括机械性血管内溶血，通常与人工心脏瓣膜功能障碍或很少见的心脏瓣膜修复有关。我们描述了一例唐氏综合征患儿，他在二尖瓣修复后发生溶血性贫血。我们观察到这种情况在儿科中是一种罕见的并发症，文献中仅报告了 7 例。在新发生的溶血性贫血的鉴别诊断中，应始终考虑机械性溶血，特别是在患有心脏瓣膜病并接受心脏手术的患者中。
