Wang Chuxin, Jeong Haksoo, Lee Jin-Sol, Maszczyk Piotr, Sayed Alaa El-Din H, Hwang Un-Ki, Kim Hyung Sik, Lee Jae-Seong, Byeon Eunjin
Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon 16419, South Korea.
School of Pharmacy, Sungkyunkwan University, Suwon 16419, South Korea.
Mar Pollut Bull. 2023 Sep;194(Pt B):115332. doi: 10.1016/j.marpolbul.2023.115332. Epub 2023 Jul 30.
Because nanoplastics (NPs) can transport pollutants, the absorption of surrounding pollutants into NPs and their effects are important environmental issues. This study shows a combined effect of high concentrations of NPs and copper (Cu) in the marine rotifer Brachionus plicatilis. Co-exposure decreased the growth rate, reproduction, and lifespan. The highest level of NP ingestion was detected in the co-treated group, but the Cu concentration was higher in the Cu single-exposure group. ERK activation played a key role in the downstream cell signaling pathway activated by the interaction of NPs and Cu. The increased sensitivity of B. plicatilis to Cu could be due to the impairment of MXR function caused by a high concentration of NPs, which supports our in vivo experiment results. Our results show that exposure to NPs could induce the dysfunction of several critical molecular responses, weakening resistance to Cu and thereby increasing its physiological toxicity in B. plicatilis.
由于纳米塑料（NPs）能够运输污染物，周围污染物被NPs吸收及其影响是重要的环境问题。本研究显示了高浓度NPs与铜（Cu）对海洋轮虫褶皱臂尾轮虫（Brachionus plicatilis）的联合作用。共同暴露降低了其生长速率、繁殖能力和寿命。在共同处理组中检测到最高水平的NP摄入量，但在Cu单一暴露组中Cu浓度更高。ERK激活在由NPs和Cu相互作用激活的下游细胞信号通路中起关键作用。褶皱臂尾轮虫对Cu敏感性增加可能是由于高浓度NPs导致MXR功能受损，这支持了我们的体内实验结果。我们的结果表明，暴露于NPs可诱导几种关键分子反应功能障碍，削弱对Cu的抗性，从而增加其在褶皱臂尾轮虫中的生理毒性。
