Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Eur Neurol. 2023;86(5):341-347. doi: 10.1159/000533297. Epub 2023 Aug 1.
In this study, we aimed to investigate changes in the total cerebellar volume, subdivisions of the cerebellar volume, and intrinsic cerebellar network in patients with isolated rapid eye movement (REM) sleep behavior disorder (iRBD) compared to healthy controls.
We enrolled patients with newly diagnosed iRBD and healthy controls who had no structural lesions according to their brain MRI. All participants underwent three-dimensional T1-weighted imaging. We obtained the total cerebellar volume and subdivisions of the cerebellar volume using the ACAPULCO program and calculated the intrinsic cerebellar network using a BRAPH program based on the subdivisions of the cerebellar volume by applying a graph theory. We compared the cerebellar volumes and intrinsic cerebellar network between the patients with iRBD and healthy controls.
In total, we enrolled 43 patients with iRBD and 47 healthy controls. Total cerebellar volume in patients with iRBD was lower than that in the healthy controls (8.4637 vs. 9.0863%, p = 0.0001). There were significant differences in the subdivisions of cerebellar volume between the groups. The volumes of the right and left lobule VIIB in the patients with iRBD were lower than those in the healthy controls (right, 0.3495 vs. 0.4025%, p = 0.0009; left, 0.3561 vs. 0.4293%, p < 0.0001). However, the other cerebellar volumes, such as the corpus meullare and vermis, were not different between the groups. The intrinsic cerebellar network was not different between the patients with iRBD and healthy controls.
We found decreased total cerebellar volumes and subdivisions of the cerebellar volume, particularly in the right and left lobule VIIB, in patients with iRBD compared to healthy controls. The present results suggest that the cerebellum may play a potential role in the pathogenesis of iRBD.
本研究旨在比较孤立性快速眼动（REM）睡眠行为障碍（iRBD）患者与健康对照者之间小脑总容积、小脑容积细分以及固有小脑网络的变化。
我们纳入了根据脑 MRI 无结构性病变新诊断为 iRBD 的患者和健康对照者。所有参与者均接受三维 T1 加权成像。我们使用 ACAPULCO 程序获得小脑总容积和小脑容积细分，并使用 BRAPH 程序基于小脑容积细分应用图论计算固有小脑网络。我们比较了 iRBD 患者与健康对照者的小脑容积和固有小脑网络。
共纳入 43 例 iRBD 患者和 47 例健康对照者。iRBD 患者的小脑总容积低于健康对照组（8.4637%比 9.0863%，p = 0.0001）。两组间小脑容积细分存在显著差异。iRBD 患者右侧和左侧 VIIB 叶的容积低于健康对照组（右侧，0.3495%比 0.4025%，p = 0.0009；左侧，0.3561%比 0.4293%，p < 0.0001）。然而，其他小脑容积，如脑桥和小脑蚓部，两组间无差异。iRBD 患者与健康对照者的固有小脑网络无差异。
与健康对照者相比，iRBD 患者的小脑总容积和小脑容积细分，尤其是右侧和左侧 VIIB 叶，减小。这些结果提示小脑可能在 iRBD 的发病机制中发挥潜在作用。
