Ege University Faculty of Medicine Department of Ophthalmology, Izmir, Turkey.
Ege University Faculty of Medicine Department of Ophthalmology, Izmir, Turkey.
Photodiagnosis Photodyn Ther. 2023 Sep;43:103726. doi: 10.1016/j.pdpdt.2023.103726. Epub 2023 Jul 30.
This study aimed to compare choroidal thickness, total choroidal area (TCA), luminal area (LA), stromal area (SA) and choroidal vascularity index (CVI) in patients with reticular pseudodrusen (RPD) and drusen.
A total of 100 eyes of 100 patients with non-neovascular age related macular degeneration (AMD) with five or more medium drusen (63-125 µm) and RPD in two or more quadrants were recruited to the study. 48 eyes of 48 patients with RPD were assigned as Group 1 and 52 eyes of 52 patients with drusen were assigned as Group 2. 40 right eyes of 40 healthy subjects were included as controls. Patients with neovascular AMD or advanced non-neovascular AMD were excluded from the study. After a detailed ophthalmic examination, infrared reflectance images and OCT with enhanced depth imaging mode was obtained from all patients. TCA, SA, LA and CVI were calculated using the Image J program. The data were analyzed for statistics using SPSS software.
The female/male ratio was 56/44 in the patient groups and 20/20 in the control group. The mean age was 73.63±6.14 (61-91) years for Group 1 and 69.43± 6.97 (59-87) years for Group 2 (p=0.005). The mean age of Group 3 patients was 71.14±8.17 (60-79) years and was statistically similar to Groups 1 and 2 (p=0.09 and p=0.12, respectively). Choroidal thickness, TCA, SA and LA were significantly lower in Group 1 (p<0.001). CVI and foveal thicknesses were not significantly different between Group 1 and 2 (p=0.214 and p=0.384 respectively). CVI was significantly lower in Group 3 (p<0.01). RPD was most commonly seen in the superior quadrant followed by temporal, nasal, and inferior quadrants.
TCA, SA and LA, which reflect choroidal vasculature, were decreased in patients with RPD. These parameters can help evaluate the pathophysiology of the disease.
本研究旨在比较网状假性色素层上皮营养不良（RPD）和玻璃膜疣患者的脉络膜厚度、总脉络膜面积（TCA）、管腔面积（LA）、基质面积（SA）和脉络膜血管指数（CVI）。
共纳入 100 例（100 只眼）非新生血管性年龄相关性黄斑变性（AMD）患者，这些患者均有 5 个或更多中等大小（63-125μm）玻璃膜疣和两个或更多象限的 RPD。其中 48 只眼（48 例患者）被分配到 RPD 组 1，52 只眼（52 例患者）被分配到玻璃膜疣组 2。另外 40 例（40 只眼）健康受试者被纳入对照组。本研究排除了新生血管性 AMD 或晚期非新生血管性 AMD 患者。所有患者均进行详细的眼科检查、红外反射图像和 OCT 增强深度成像模式检查。使用 Image J 程序计算 TCA、SA、LA 和 CVI。使用 SPSS 软件对数据进行统计分析。
患者组中女性/男性比例为 56/44，对照组为 20/20。RPD 组 1 的平均年龄为 73.63±6.14 岁（61-91 岁），玻璃膜疣组 2 的平均年龄为 69.43±6.97 岁（59-87 岁）（p=0.005）。RPD 组 3 患者的平均年龄为 71.14±8.17 岁（60-79 岁），与 RPD 组 1 和玻璃膜疣组 2 相比差异无统计学意义（p=0.09 和 p=0.12）。RPD 组 1 的脉络膜厚度、TCA、SA 和 LA 均显著降低（p<0.001）。RPD 组 1 和玻璃膜疣组 2 的 CVI 和黄斑中心凹厚度无显著差异（p=0.214 和 p=0.384）。RPD 组 3 的 CVI 显著降低（p<0.01）。RPD 最常发生于上象限，其次是颞侧、鼻侧和下象限。
RPD 患者的脉络膜厚度、TCA、SA 和 LA 等反映脉络膜血管的参数降低。这些参数有助于评估疾病的病理生理学。
