线粒体酸5可减轻秀丽隐杆线虫中与线粒体钙超载相关的衰老相关神经肌肉功能障碍。
Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca overload in Caenorhabditis elegans.
作者信息
Wu XinTong, Seida Miku, Abe Takaaki, Higashitani Atsushi
机构信息
Graduate School of Life Sciences, Tohoku University, Sendai, 980-8577, Japan.
Division of Medical Science, Tohoku University Graduate School of Biomedical Engineering, Sendai, 980-0872, Japan.
出版信息
NPJ Aging. 2023 Aug 1;9(1):20. doi: 10.1038/s41514-023-00116-2.
Mitochonic acid-5 ameliorates the pathophysiology of human mitochondrial-disease fibroblasts and Caenorhabditis elegans Duchenne muscular dystrophy and Parkinson's disease models. Here, we found that 10 μM MA-5 attenuates the age-related decline in motor performance, loss of muscle mitochondria, and degeneration of dopaminergic neurons associated with mitochondrial Ca overload in C. elegans. These findings suggest that MA-5 may act as an anti-aging agent against a wide range of neuromuscular dysfunctions in metazoans.
线粒体酸 -5 改善了人类线粒体疾病成纤维细胞以及秀丽隐杆线虫杜兴氏肌营养不良症和帕金森病模型的病理生理学。在此，我们发现 10 μM 的 MA -5 可减轻秀丽隐杆线虫中与线粒体钙超载相关的运动性能随年龄的下降、肌肉线粒体的丧失以及多巴胺能神经元的退化。这些发现表明，MA -5 可能作为一种抗衰老剂，对抗后生动物中广泛的神经肌肉功能障碍。
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