Nephrology and Hypertension, Oregon Health & Science University School of Medicine, Portland, Oregon.
Katz Family Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida.
Kidney360. 2023 Oct 1;4(10):1503-1511. doi: 10.34067/KID.0000000000000230.
Management of lupus nephritis has evolved considerably over the past years. Here, we provide a comprehensive review of clinical trials that form the basis for the Kidney Disease: Improving Global Outcomes and EULAR/ERA-EDTA updated guidelines and present day trials that will change the landscape of lupus nephritis therapy in years to come. In addition, we highlight the issues related to cost of therapy, resistant disease, and downstream adverse effects of specific therapies.
狼疮肾炎的治疗在过去几年中已有了显著的发展。在这里，我们对构成改善全球肾脏病预后组织（KDIGO）和欧洲抗风湿病联盟/欧洲肾脏学会- 血管紧张素转化酶抑制剂分会（EULAR/ERA-EDTA）更新指南基础的临床试验进行了全面回顾，并介绍了目前的临床试验，这些试验将在未来几年改变狼疮肾炎治疗的格局。此外，我们还强调了与治疗成本、耐药疾病以及特定治疗方法的下游不良影响相关的问题。
