Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Serviço de Imagiologia Neurológica, Centro Hospitalar Universitário Lisboa Norte, EPE, Lisboa, Portugal.
Mult Scler. 2023 Sep;29(10):1250-1256. doi: 10.1177/13524585231188485. Epub 2023 Aug 1.
The effect of smoking on the resolution of magnetic resonance imaging (MRI) lesions in patients with neuromyelitis optica spectrum disorders with aquaporin-4 positive antibody (NMOSD-AQP4) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) has not been studied before.
We aimed to determine the effect of smoking on lesion resolution in MRI and assess its correlation with clinical recovery after a relapse.
We conducted a cohort study including NMOSD-AQP4 and MOGAD patients with acute and follow-up MRI scans. We collected demographic, clinical, imaging and smoking data. Logistic regression models were fitted to predict the effect of smoking on lesion resolution and to assess whether clinical recovery was associated with MRI lesion resolution.
A total of 105 patients were included (57 with NMOSD-AQP4 and 48 with MOGAD). Current and past smoking was associated with a higher risk of persistent lesions in NMOSD-AQP4 and MOGAD (risk ratio (RR) = 3.4, 95% confidence interval (CI) = 2.5-4.7, < 0.001). Additionally, the presence of lesion resolution was associated with better clinical recovery (RR = 1.9, 95% CI = 1.7-2.2, < 0.001).
Smoking is associated with worse MRI lesion resolution in patients with NMOSD-AQP4 and MOGAD, and lesion resolution correlates with clinical recovery. Our findings suggest a detrimental effect of smoking in inflammatory central nervous system (CNS) diseases.
吸烟对水通道蛋白 4 阳性抗体（NMOSD-AQP4）和髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）的视神经脊髓炎谱系障碍患者磁共振成像（MRI）病变消退的影响尚未被研究过。
我们旨在确定吸烟对 MRI 病变消退的影响，并评估其与复发后临床恢复的相关性。
我们进行了一项队列研究，纳入了具有急性和随访 MRI 扫描的 NMOSD-AQP4 和 MOGAD 患者。我们收集了人口统计学、临床、影像学和吸烟数据。使用逻辑回归模型来预测吸烟对病变消退的影响，并评估临床恢复是否与 MRI 病变消退相关。
共纳入 105 例患者（57 例 NMOSD-AQP4 和 48 例 MOGAD）。目前和过去吸烟与 NMOSD-AQP4 和 MOGAD 患者持续性病变的风险增加相关（风险比（RR）=3.4，95%置信区间（CI）=2.5-4.7，<0.001）。此外，病变消退与更好的临床恢复相关（RR=1.9，95%CI=1.7-2.2，<0.001）。
吸烟与 NMOSD-AQP4 和 MOGAD 患者的 MRI 病变消退不良相关，病变消退与临床恢复相关。我们的研究结果表明吸烟对炎症性中枢神经系统（CNS）疾病有不利影响。
