Cripto-1 在早期非小细胞肺癌中的表达及预后价值。
Expression and prognostic value of Cripto-1 in early non-small cell lung cancer.
机构信息
Department of Thoracic Surgery, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.
Department of Respiratory Medicine, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, China.
出版信息
Clin Respir J. 2023 Dec;17(12):1203-1208. doi: 10.1111/crj.13680. Epub 2023 Aug 1.
OBJECTIVE
We aim to explore the expression of Cripto-1 (CR-1) protein in patients with early stage non-small cell lung cancer (NSCLC).
METHODS
We investigated CR-1 expression status in specimens obtained from 240 patients with resected NSCLC and 30 cases of para-carcinous normal lung tissues.
RESULTS
Compared with normal lung tissue, the positive expression of CR-1 protein in NSCLC was significantly increased (p < 0.005). Cox multivariate regression analysis showed that the expression of CR-1 protein was an independent prognostic factor for early stage NSCLC (p = 0.002).
CONCLUSION
Detecting CR-1 protein can predict the prognosis and recurrence in patients with NSCLC.
目的
本研究旨在探讨早期非小细胞肺癌（NSCLC）患者中 Cripto-1（CR-1）蛋白的表达情况。
方法
本研究检测了 240 例接受手术治疗的 NSCLC 患者和 30 例癌旁正常肺组织标本中 CR-1 的表达状态。
结果
与正常肺组织相比，NSCLC 中 CR-1 蛋白的阳性表达显著增加（p<0.005）。Cox 多因素回归分析显示，CR-1 蛋白的表达是早期 NSCLC 的独立预后因素（p=0.002）。
结论
检测 CR-1 蛋白可预测 NSCLC 患者的预后和复发情况。
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