Stem Cell Biochemistry Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
EMBO J. 2023 Sep 4;42(17):e114931. doi: 10.15252/embj.2023114931. Epub 2023 Aug 2.
The CUL4 paralogs CUL4A and CUL4B assemble into structurally similar multisubunit ubiquitin E3 ligases (CRL4A/B) that regulate diverse aspects of cell biology. New work in this issue of The EMBO Journal shows that the longer N-terminal tail of CUL4B tells these molecular twins apart, by promoting the formation of paralog-specific CRL4B complexes that control cytoskeletal processes during mitosis and brain development.
CUL4 同源物 CUL4A 和 CUL4B 组装成结构相似的多亚基泛素 E3 连接酶 (CRL4A/B)，调节细胞生物学的各个方面。本期《欧洲分子生物学组织杂志》的新工作表明，CUL4B 更长的 N 端尾巴通过促进形成特定于同源物的 CRL4B 复合物，将这对分子双胞胎区分开来，从而控制有丝分裂和大脑发育过程中的细胞骨架过程。
