Kattner Nicole
Translational and Clinical Research Institute, Newcastle University, Medical School, Framlington Place, Newcastle upon Tyne, UK.
Ther Adv Endocrinol Metab. 2023 Jul 25;14:20420188231185958. doi: 10.1177/20420188231185958. eCollection 2023.
The different types of diabetes differ in disease pathogenesis but share the impairment or loss of β-cell function leading to chronic hyperglycaemia. While immune cells are present throughout the whole pancreas in normality, their number and activation is increased in diabetes. Different patterns and composition of inflammation could be observed in type 1, type 2 and type 3c diabetes. Immune cells, pancreatic stellate cells and fibrosis were present in the islet microenvironment and could add to β-cell dysfunction and therefore development and progression of diabetes. First studies investigating the use of anti-inflammatory drugs demonstrate their ability to rescue remaining β-cell function and their potential benefit in diabetes treatment. This article provides an overview of immune cell infiltrates in different types of diabetes, highlights the knowledge of their impact on β-cell function and introduces the potential of immunomodulatory strategies.
不同类型的糖尿病在疾病发病机制上存在差异，但都存在β细胞功能受损或丧失，从而导致慢性高血糖。在正常情况下，免疫细胞遍布整个胰腺，但在糖尿病患者中其数量和活性会增加。在1型、2型和3c型糖尿病中可观察到不同的炎症模式和组成。免疫细胞、胰腺星状细胞和纤维化存在于胰岛微环境中，可能会加重β细胞功能障碍，进而影响糖尿病的发生和发展。最初关于使用抗炎药物的研究表明，它们能够挽救剩余的β细胞功能，并在糖尿病治疗中具有潜在益处。本文概述了不同类型糖尿病中的免疫细胞浸润情况，强调了它们对β细胞功能影响的相关知识，并介绍了免疫调节策略的潜力。
