Tari K, Satake I, Kojima S, Owada F
Gan To Kagaku Ryoho. 1986 Sep;13(9):2848-52.
A new neuroleptic drug, Timiperone, is able to exert an antiapomorphine effect at doses smaller than cataleptogenic doses. Nineteen patients with urologic malignancy undergoing chemotherapy with cisplatin in combination with other agents were studied for the antiemetic efficacy of Timiperone. Six of 8 patients over 46 years old treated with Timiperone 6 mg/day p.o. from the day before undergoing DDP therapy to the last day of the therapy had no episode of vomiting and 2 patients had a few episodes of emesis (one and two episodes during 5 days of undergoing DDP, respectively). Five patients under 45 years old given Timiperone 6 mg/day by the same method had few episodes of vomiting, but suffered from extrapyramidal symptoms. Finally 6 patients undergoing DDP with Timiperone in combination with trihexyphenidyl suffered no symptoms of catalepsy but sometimes had mild vomiting episodes (1-4 times a day). We would like to propose that in antiemetic therapy with Timiperone for cisplatin-induced nausea and vomiting, a dose of 4.5 mg/day be given from two days before undergoing chemotherapy because of the cumulative effect of Timiperone.
一种新型抗精神病药物替米哌隆，在剂量小于致僵剂量时就能发挥抗阿扑吗啡作用。对19例接受顺铂联合其他药物化疗的泌尿系统恶性肿瘤患者进行了替米哌隆止吐疗效的研究。8例46岁以上患者中，6例从顺铂治疗前一天至治疗最后一天口服替米哌隆6mg/天，未发生呕吐，2例有少量呕吐发作（顺铂治疗5天期间分别为1次和2次）。5例45岁以下患者采用相同方法给予替米哌隆6mg/天，呕吐发作较少，但出现锥体外系症状。最后，6例接受顺铂治疗并联合使用替米哌隆和苯海索的患者未出现僵住症状，但有时有轻度呕吐发作（每天1 - 4次）。鉴于替米哌隆的累积效应，我们建议在使用替米哌隆治疗顺铂引起的恶心和呕吐时，应在化疗前两天开始给予4.5mg/天的剂量。
