Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan.
Org Lett. 2023 Aug 11;25(31):5745-5749. doi: 10.1021/acs.orglett.3c01932. Epub 2023 Aug 2.
Convergent total synthesis of (+)-muricatetrocin B, a tetrahydrofuran-containing acetogenin with potent and selective cytotoxicity against the HT-29 human colon adenocarcinoma cell line, was achieved in 13 steps. Our synthesis is highlighted by a late-stage sequential olefin cross-metathesis/Hartung-Mukaiyama cyclization for convergent assembly of the 2,5--substituted tetrahydrofuran ring.
（+）-muricatetrocin B 的汇聚全合成，一种含有四氢呋喃的乙酰生肌肽，对 HT-29 人结肠腺癌细胞系具有强大和选择性的细胞毒性，通过 13 步实现。我们的合成以晚期顺序烯烃交叉复分解/Hartung-Mukaiyama 环化反应为特色，用于 2,5--取代的四氢呋喃环的汇聚组装。
