Bapuji Educational Association's J.J.M. Medical College, Davangere, Karnataka, India.
Aga Khan University, Karachi, Pakistan.
BJOG. 2023 Nov;130 Suppl 3:53-60. doi: 10.1111/1471-0528.17614. Epub 2023 Aug 2.
Group B streptococcus (GBS) has been associated with adverse pregnancy outcomes, but few prospective studies have assessed its prevalence in low- and middle-income country settings. We sought to evaluate the prevalence of GBS by polymerase chain reaction (PCR) in internal organ tissues and placentas of deceased neonates and stillbirths.
This was a prospective, observational study.
The study was conducted in hospitals in India and Pakistan.
Pregnant women with stillbirths or preterm births were recruited at delivery, as was a group of women with term, live births, to serve as a control group.
A rectovaginal culture was collected from the women in Pakistan to assess GBS carriage. Using PCR, we evaluated GBS in various tissues of stillbirths and deceased neonates and their placentas, as well as the placentas of live-born preterm and term control infants.
GBS identified by PCR in various tissues and the placentas; rate of stillbirths and 28-day neonatal deaths.
The most obvious finding from this series of analyses from India and Pakistan was that no matter the country, the condition of the subject, the tissue studied or the methodology used, the prevalence of GBS was low, generally ranging between 3% and 6%. Among the risk factors evaluated, only GBS positivity in primigravidae was increased.
GBS diagnosed by PCR was identified in <6% of internal organs of stillbirths and neonatal deaths, and their placentas, and control groups in South Asian sites. This is consistent with other reports from South Asia and is lower than the reported GBS rates from the USA, Europe and Africa.
B 组链球菌（GBS）与不良妊娠结局有关，但很少有前瞻性研究评估其在中低收入国家的流行率。我们旨在通过聚合酶链反应（PCR）评估死产儿和死胎的内部器官组织和胎盘中 GBS 的流行率。
这是一项前瞻性、观察性研究。
这项研究在印度和巴基斯坦的医院进行。
在分娩时招募了死产或早产的孕妇，以及一组足月、活产的孕妇作为对照组。
从巴基斯坦的妇女中采集直肠阴道培养物，以评估 GBS 携带情况。我们使用 PCR 评估了死产儿和死亡新生儿的各种组织及其胎盘中的 GBS，以及活产早产儿和足月对照组婴儿的胎盘中的 GBS。
PCR 鉴定的各种组织和胎盘中的 GBS；死产率和 28 天新生儿死亡率。
从印度和巴基斯坦的一系列分析中最明显的发现是，无论国家、研究对象的状况、研究的组织还是使用的方法，GBS 的流行率都很低，通常在 3%至 6%之间。在评估的风险因素中，只有初产妇的 GBS 阳性率增加。
在南亚地区的研究地点，通过 PCR 诊断的 GBS 在<6%的死产儿和新生儿死亡的内部器官及其胎盘和对照组中被发现。这与来自南亚的其他报告一致，且低于来自美国、欧洲和非洲的报告 GBS 率。
