Moreau S, Charet P, Prensier G
Ann Trop Med Parasitol. 1986 Apr;80(2):169-76. doi: 10.1080/00034983.1986.11812001.
The affinity to haematin of antimalarial drugs and of some closely related compounds has been measured by the use of a polymeric haematin linked to an agarose gel. Haematin-drug interaction shows a low specificity and does not exhibit the sharp structure-activity relationship observed in the biological activities of the compounds. It is suggested that a chloroquine-haematin interaction does not explain the biological properties of this antimalarial, although it constitutes a necessary step in the concentration of the drug in the parasitized erythrocyte.
