Help on the way to unsilence HbF.
作者信息
Dean Ann
机构信息
National Institute of Diabetes and Digestive and Kidney Diseases.
出版信息
Blood. 2023 Jun 1;141(22):2670-2672. doi: 10.1182/blood.2023020345.
Abstract
摘要
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Help on the way to unsilence HbF.使胎儿血红蛋白不再沉默的方法即将出现。
Blood. 2023 Jun 1;141(22):2670-2672. doi: 10.1182/blood.2023020345.
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本文引用的文献
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Molecular basis of polycomb group protein-mediated fetal hemoglobin repression.多梳蛋白介导的胎儿血红蛋白抑制的分子基础。
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2
CRISPR-Cas9 to induce fetal hemoglobin for the treatment of sickle cell disease.利用CRISPR-Cas9诱导胎儿血红蛋白治疗镰状细胞病。
Mol Ther Methods Clin Dev. 2021 Oct 1;23:276-285. doi: 10.1016/j.omtm.2021.09.010. eCollection 2021 Dec 10.
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The molecular principles of gene regulation by Polycomb repressive complexes.多梳抑制复合物调控基因表达的分子机制。
Nat Rev Mol Cell Biol. 2021 Dec;22(12):815-833. doi: 10.1038/s41580-021-00398-y. Epub 2021 Aug 16.
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Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis.通过全面的原位诱变指导 NuRD 亚复合物的合理靶向。
Nat Genet. 2019 Jul;51(7):1149-1159. doi: 10.1038/s41588-019-0453-4. Epub 2019 Jun 28.
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Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathies.血红蛋白病中血红蛋白开关理解和操作的最新进展。
Br J Haematol. 2018 Mar;180(5):630-643. doi: 10.1111/bjh.15038. Epub 2017 Nov 28.
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IGF2BP1 overexpression causes fetal-like hemoglobin expression patterns in cultured human adult erythroblasts.IGF2BP1 过表达导致培养的人成红细胞中出现胎儿样血红蛋白表达模式。
Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5664-E5672. doi: 10.1073/pnas.1609552114. Epub 2017 Jun 26.
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LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo.LIN28B 介导的胎儿血红蛋白表达和体外成人红细胞生成胎儿样红细胞。
Blood. 2013 Aug 8;122(6):1034-41. doi: 10.1182/blood-2012-12-472308. Epub 2013 Jun 24.
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Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A.BCL11A 通过核心抑制因子依赖性沉默胎儿血红蛋白的表达。
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