Gilbert R, Auchincloss J H
Arch Intern Med. 1986 Sep;146(9):1779-81.
We studied 211 sets of pulmonary function data to evaluate spirographic findings in patients with restrictive defects, and to determine the significance of the spirographic interpretation of restriction. A combination of clinical and body plethysmographic data was used as the standard for the diagnosis of restriction. Restriction was diagnosed spirographically when forced vital capacity (FVC) was low and the ratio of one-second forced expiratory volume (FEV1) to FVC (FEV1/FVC%) was normal. With these criteria, using 70% as the lower limit of normal for FEV1/FVC%, the spirogram had a 93% sensitivity and an 82% specificity for the detection or exclusion of a restrictive defect. Ten percent of patients with pure obstructive defects by clinical and plethysmographic criteria showed a restrictive defect on the spirogram. Combined obstructive and restrictive defects were rare; in these cases the spirogram showed a restrictive defect but missed the obstructive component.
我们研究了211组肺功能数据，以评估限制性缺陷患者的肺量计检查结果，并确定肺量计对限制性通气功能障碍解读的意义。临床和体容积描记数据的组合被用作诊断限制性通气功能障碍的标准。当用力肺活量（FVC）降低且一秒用力呼气容积（FEV1）与FVC的比值（FEV1/FVC%）正常时，通过肺量计诊断为限制性通气功能障碍。根据这些标准，将FEV1/FVC%的正常下限设定为70%，肺量计检测或排除限制性缺陷的敏感性为93%，特异性为82%。根据临床和体容积描记标准诊断为单纯阻塞性缺陷的患者中，有10%在肺量计检查中显示为限制性缺陷。混合性阻塞性和限制性缺陷很少见；在这些病例中，肺量计显示为限制性缺陷，但遗漏了阻塞性成分。
