Adler E, Benjamin S B, Zimmerman H J
Arch Intern Med. 1986 Sep;146(9):1837-9.
Despite the widespread use of oral anticoagulants derived from 4-hydroxycoumarin, there have been only a small number of well-defined cases of hepatotoxicity. We report a well-defined case of cholestasis following exposure to warfarin sodium (Coumadin). Inadvertent rechallenge reproduced the syndrome. Cholestasis may occur in response to exposure to derivations of 4-hydroxycoumarin.
尽管源自4-羟基香豆素的口服抗凝剂被广泛使用，但仅有少数明确的肝毒性病例。我们报告一例明确的华法林钠（香豆素）暴露后胆汁淤积病例。意外再次激发重现了该综合征。胆汁淤积可能因暴露于4-羟基香豆素衍生物而发生。
