Wang Peng-Zi, Chen Jia-Rong, Xiao Wen-Jing
College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China.
Wuhan Institute of Photochemistry and Technology, 7 North Bingang Road, Wuhan, Hubei 430083, China.
J Am Chem Soc. 2023 Aug 16;145(32):17527-17550. doi: 10.1021/jacs.3c04879. Epub 2023 Aug 2.
The C-O bond is ubiquitous in biologically active molecules, pharmaceutical agents, and functional materials, thereby making it an important functional group. Consequently, the development of C-O bond-forming reactions using catalytic strategies has become an increasingly important research topic in organic synthesis because more conventional methods involving strong base and acid have many limitations. In contrast to the ionic-pathway-based methods, copper-promoted radical-mediated C-O bond formation is experiencing a surge in research interest owing to a renaissance in free-radical chemistry and photoredox catalysis. This highlights and appraises state-of-the-art techniques in this burgeoning research field. The contents are organized according to the different reaction types and working models.
碳-氧键在生物活性分子、药物制剂和功能材料中普遍存在，因此它是一个重要的官能团。因此，利用催化策略形成碳-氧键的反应发展已成为有机合成中一个日益重要的研究课题，因为更多涉及强碱和强酸的传统方法存在许多局限性。与基于离子途径的方法不同，由于自由基化学和光氧化还原催化的复兴，铜促进的自由基介导的碳-氧键形成正受到越来越多的研究关注。本文重点介绍并评估了这一新兴研究领域的前沿技术。内容根据不同的反应类型和工作模式进行组织。
