Endocrinology - Diabetology - Nutrition Unit, University Hospital Rennes, France.
Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts at Amherst, Amherst, MA, USA; Scripps Institution of Oceanography, University of California, San Diego, USA; Paris-Saclay University, UVSQ, Univ. Paris-Sud, Inserm, Gustave Roussy, "Exposome and Heredity" team, CESP, Villejuif, France.
Maturitas. 2023 Nov;177:107805. doi: 10.1016/j.maturitas.2023.107805. Epub 2023 Jul 28.
Several studies suggest an association between endometriosis and the risk of cardio-metabolic diseases. This study aimed to prospectively evaluate the association between history of endometriosis and incident type 2 diabetes.
E3N is a prospective cohort of 98,995 French women aged 40-65 years at inclusion. Multivariable Cox regression models were used to estimate hazard ratios and 95 % confidence intervals for the association between endometriosis and incident type 2 diabetes. We evaluated effect modification by age, body mass index, infertility treatment, adherence to the Mediterranean diet, and menopausal status.
Age at inclusion was 51 ± 6 years and there were 2672 incident cases of type 2 diabetes. A total of 4606 women reported surgically-confirmed endometriosis among 83,582 women with no history of diabetes at inclusion. Endometriosis was not associated with type 2 diabetes risk in a model adjusted for age, BMI, physical activity, smoking, education, age at menarche and oral contraceptive use (hazard ratio [HR] = 1.09; 95 % confidence interval [CI] = 0.92-1.29), neither after further adjustment for family history of diabetes, hypertension and menopausal status (HR = 0.97;95%CI = 0.80-1.16). The relationship did not differ by age at inclusion, BMI, infertility treatment, diet or menopausal status (p > 0.05).
Surgically-confirmed endometriosis was not associated with the risk of type 2 diabetes in this large cohort, confirming that endometriosis is not a risk marker for type 2 diabetes.
多项研究表明子宫内膜异位症与心血管代谢疾病的风险之间存在关联。本研究旨在前瞻性评估子宫内膜异位症病史与 2 型糖尿病发病风险之间的关系。
E3N 是一项前瞻性队列研究，纳入了 98995 名年龄在 40-65 岁的法国女性。多变量 Cox 回归模型用于估计子宫内膜异位症与 2 型糖尿病发病风险之间的关联的风险比和 95%置信区间。我们评估了年龄、体重指数、不孕治疗、遵循地中海饮食和绝经状态的效应修饰作用。
纳入时的年龄为 51±6 岁，有 2672 例 2 型糖尿病发病。在没有糖尿病病史的 83582 名女性中，共有 4606 名女性报告了经手术证实的子宫内膜异位症。在调整年龄、BMI、身体活动、吸烟、教育、初潮年龄和口服避孕药使用的模型中，子宫内膜异位症与 2 型糖尿病风险无关（风险比[HR] = 1.09；95%置信区间[CI] = 0.92-1.29），进一步调整糖尿病、高血压和绝经状态家族史后也是如此（HR = 0.97；95%CI = 0.80-1.16）。这种关系不受纳入时的年龄、BMI、不孕治疗、饮食或绝经状态的影响（p>0.05）。
在这项大型队列研究中，经手术证实的子宫内膜异位症与 2 型糖尿病的发病风险无关，证实了子宫内膜异位症不是 2 型糖尿病的风险标志物。
