College of Food Science and Engineering, Jilin University, Changchun, 130062, China.
College of Food Science and Engineering, Jilin University, Changchun, 130062, China.
Food Chem Toxicol. 2023 Sep;179:113976. doi: 10.1016/j.fct.2023.113976. Epub 2023 Jul 31.
The pregnane X receptor (PXR) is a kind of orphan nuclear receptor activated by a series of ligands. Environmental endocrine disruptors (EEDs) are a wide class of molecules present in the environment that are suspected to have adverse effects on the endocrine system by interfering with the synthesis, transport, degradation, or action of endogenous hormones. Since EEDs may modulate human/rodent PXR, this review aims to summarize EEDs as PXR modulators, including agonists and antagonists. The modular structure of PXR is also described, interestingly, the pharmacology of PXR have been confirmed to vary among different species. Furthermore, PXR play a key role in the regulation of endocrine function. Endocrine disruption of EEDs via PXR and its related pathways are systematically summarized. In brief, this review may provide a way to understand the roles of EEDs in interaction with the nuclear receptors (such as PXR) and the related pathways.
妊娠相关 X 受体 (PXR) 是一种孤儿核受体，可被一系列配体激活。环境内分泌干扰物 (EEDs) 是一类广泛存在于环境中的分子，它们被怀疑通过干扰内源性激素的合成、运输、降解或作用对内分泌系统产生不良影响。由于 EEDs 可能调节人和啮齿动物的 PXR，因此本综述旨在总结 EEDs 作为 PXR 调节剂，包括激动剂和拮抗剂。还描述了 PXR 的模块化结构，有趣的是，PXR 的药理学已被证实在不同物种之间存在差异。此外，PXR 在调节内分泌功能方面发挥着关键作用。通过 PXR 及其相关途径对 EEDs 的内分泌干扰进行了系统总结。总之，本综述可能为了解 EEDs 与核受体（如 PXR）及其相关途径相互作用提供了一种途径。
