Uro-Oncology Division, Department of Surgical Oncology, Mahamana Pandit Madan Mohan Malviya Cancer Centre (MPMMCC) & Homi Bhabha Cancer Hospital (HBCH), Varanasi, India.
Department of Pathology, Mahamana Pandit Madan Mohan Malviya Cancer Centre (MPMMCC) & Homi Bhabha Cancer Hospital (HBCH), Varanasi, India.
BMC Urol. 2023 Aug 2;23(1):131. doi: 10.1186/s12894-023-01302-w.
Solitary fibrous tumors (SFTs) are very rare spindle cell neoplasms of mesenchymal origin with largely benign course of disease. Genital SFT's can be managed providing excellent functional and psychological outcomes by timely intervention.
We report the largest and possibly the second only reported case of penile SFT in a 34 year male presenting with a gradually increasing perineal mass with clinically normal appearing phallus. MRI revealed a 9.8 × 3.2 cm soft tissue mass arising from left corpora cavernosae, the mass was excised en-bloc via a perineal approach under spinal anaesthesia. Histopathology revealed spindle cell tumor embedded in myxohyaline stroma along with hyalinized vascular channels demonstrating IHC positivity for CD34 and STAT6. The patient is disease free post 2 years of resection with no sexual or urinary dysfunctions.
Genital SFTs, although rare, should be considered in the differential diagnosis of well-circumscribed, painless, slow growing solid masses and histopathologists must be vigilant of its malignant characteristics.
孤立性纤维瘤(SFT)是一种非常罕见的间叶来源的梭形细胞肿瘤,其病程大多为良性。通过及时干预,生殖器 SFT 可以得到很好的治疗,从而获得良好的功能和心理结果。
我们报告了一例最大的、可能也是第二例报道的 34 岁男性阴茎 SFT 病例,该患者表现为逐渐增大的会阴肿块,而外观正常的阴茎无任何异常。MRI 显示起源于左侧海绵体的 9.8×3.2cm 的软组织肿块,该肿块在脊髓麻醉下通过会阴入路整块切除。组织病理学显示,梭形细胞瘤嵌入黏液样基质中,伴有玻璃样变性的血管通道,免疫组织化学显示 CD34 和 STAT6 阳性。患者在切除后 2 年无疾病复发,无性功能或尿功能障碍。
生殖器 SFT 虽然罕见,但在鉴别诊断边界清楚、无痛、生长缓慢的实性肿块时应考虑到它,组织病理学家必须警惕其恶性特征。